Casein kinase I: another cog in the circadian clockworks.

Published

Journal Article (Review)

Multiple components of the circadian central clock are phosphoproteins, and it has become increasingly clear that posttranslational modification is an important regulator of circadian rhythm in diverse organisms, from dinoflagellates to humans. Genetic studies in Drosophila have identified double-time (dbt), a serine/threonine protein kinase that is highly homologous to human casein kinase I epsilon (CKIepsilon), as the first kinase linked to behavioral rhythms. Identification of a missense mutation in CKIepsilon as the tau mutation in the Syrian hamster places CKIepsilon within the core clock machinery in mammals. Most recently, identification of a phosphorylation site mutant of hPER2 in a family with an inherited circadian rhythm abnormality strongly suggests that PER2 is a physiologically relevant substrate of CKI. Phosphorylation may regulate multiple properties of clock proteins, including stability and intracellular localization.

Full Text

Duke Authors

Cited Authors

  • Eide, EJ; Virshup, DM

Published Date

  • May 2001

Published In

Volume / Issue

  • 18 / 3

Start / End Page

  • 389 - 398

PubMed ID

  • 11475410

Pubmed Central ID

  • 11475410

Electronic International Standard Serial Number (EISSN)

  • 1525-6073

International Standard Serial Number (ISSN)

  • 0742-0528

Digital Object Identifier (DOI)

  • 10.1081/cbi-100103963

Language

  • eng