Post-translational modifications regulate the ticking of the circadian clock.

Published

Journal Article (Review)

Getting a good night's sleep is on everyone's to-do list. So is, no doubt, staying awake during late afternoon seminars. Our internal clocks control these and many more workings of the body, and disruptions of the circadian clocks predispose individuals to depression, obesity and cancer. Mutations in kinases and phosphatases in hamsters, flies, fungi and humans highlight how our timepieces are regulated and provide clues as to how we might be able to manipulate them.

Full Text

Duke Authors

Cited Authors

  • Gallego, M; Virshup, DM

Published Date

  • February 2007

Published In

Volume / Issue

  • 8 / 2

Start / End Page

  • 139 - 148

PubMed ID

  • 17245414

Pubmed Central ID

  • 17245414

Electronic International Standard Serial Number (EISSN)

  • 1471-0080

International Standard Serial Number (ISSN)

  • 1471-0072

Digital Object Identifier (DOI)

  • 10.1038/nrm2106

Language

  • eng