Venous gas emboli and complement activation after deep repetitive air diving.

Published

Journal Article

Complement activity has been linked to decompression sickness (DCS), but the effects of intravascular bubbles on complement activation are poorly understood. We have investigated intravascular complement activation by measuring red blood cell (RBC)-bound C3d after repetitive air diving in man. Subjects were exposed to a single, 20 min, 170 fsw (feet of sea water) dive, or to 2 such dives with a 6-h surface interval. Doppler monitoring for venous gas emboli was performed postdive. Predive blood samples were studied to determine sensitivity of complement to activation by air bubbles. Other predive and postdive venous samples were evaluated for intravascular complement activation. No cases of DCS occurred in 39 dives. Baseline complement sensitivity appeared normally distributed, thus "sensitive" and "insensitive" subjects were not clearly distinguishable. RBC-bound C3d did not increase after 1 dive but did increase after the repetitive dive (P less than 0.05). Furthermore, maximum bubble grade was independent of complement activation.

Full Text

Duke Authors

Cited Authors

  • Zhang, J; Fife, CE; Currie, MS; Moon, RE; Piantadosi, CA; Vann, RD

Published Date

  • July 1991

Published In

Volume / Issue

  • 18 / 4

Start / End Page

  • 293 - 302

PubMed ID

  • 1887517

Pubmed Central ID

  • 1887517

International Standard Serial Number (ISSN)

  • 0093-5387

Language

  • eng

Conference Location

  • United States