The effect of ionised magnesium on coagulation using thromboelastography.


Journal Article

Magnesium is an ionised mineral with therapeutic uses. There is laboratory evidence that it may have an anticoagulant activity although recent research has been to the contrary. The clinical implications of the effect of a therapeutic dose of magnesium on coagulation have yet to be resolved conclusively. In our study, 10 healthy volunteers were given 4 g of magnesium sulphate intravenously. Thromboelastographs were recorded and blood analysed for haematological indices, before and after the infusion. All variables associated with coagulation remained unchanged except the alpha angle on the thromboelastograph which increased significantly. We conclude that in our in vivo study, the effect of magnesium sulphate on coagulation is not clinically significant.

Full Text

Duke Authors

Cited Authors

  • Ames, WA; McDonnell, N; Potter, D

Published Date

  • October 1999

Published In

Volume / Issue

  • 54 / 10

Start / End Page

  • 999 - 1001

PubMed ID

  • 10540068

Pubmed Central ID

  • 10540068

International Standard Serial Number (ISSN)

  • 0003-2409

Digital Object Identifier (DOI)

  • 10.1046/j.1365-2044.1999.00647.x


  • eng

Conference Location

  • England