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N omega-nitro-L-arginine methyl ester selectively inhibits pulmonary vasodilator responses to acetylcholine and bradykinin.

Publication ,  Journal Article
McMahon, TJ; Hood, JS; Bellan, JA; Kadowitz, PJ
Published in: J Appl Physiol (1985)
November 1991

The effects of N omega-nitro-L-arginine methyl ester (L-NAME), an inhibitor of endothelium-derived relaxing factor (EDRF) production, on vascular tone and responses were investigated in the pulmonary vascular bed of the intact-chest cat under conditions of controlled blood flow and constant left atrial pressure. When pulmonary vascular tone was elevated with U-46619, intralobar injections of acetylcholine, bradykinin, sodium nitroprusside, isoproterenol, prostaglandin E1 (PGE1), lemakalim, and 8-bromo-guanosine 3',5'-cyclic monophosphate (8-bromo-cGMP) dilated the pulmonary vascular bed. Intravenous administration of L-NAME elevated lobar arterial and systemic arterial pressures without altering left atrial pressure. When U-46619 was infused after L-NAME to raise lobar arterial pressure to levels similar to those attained during the control period, vasodilator responses to acetylcholine and bradykinin were reduced significantly, whereas responses to PGE1, lemakalim, and 8-bromo-cGMP were not altered, and responses to nitroprusside were increased. There was a small effect on the response to the highest dose of isoproterenol, and pressor responses to BAY K 8644 and angiotensin II were not altered. These results are consistent with the hypothesis that EDRF production may involve the formation of nitric oxide or a nitroso compound from L-arginine and that EDRF production may have a role in the regulation of tone and in the mediation of responses to acetylcholine and bradykinin in the pulmonary vascular bed of the cat.

Duke Scholars

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

November 1991

Volume

71

Issue

5

Start / End Page

2026 / 2031

Location

United States

Related Subject Headings

  • Vasodilation
  • Pulmonary Circulation
  • Physiology
  • Nitroprusside
  • Nitric Oxide
  • NG-Nitroarginine Methyl Ester
  • Male
  • Isoproterenol
  • Female
  • Cyclic GMP
 

Citation

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McMahon, T. J., Hood, J. S., Bellan, J. A., & Kadowitz, P. J. (1991). N omega-nitro-L-arginine methyl ester selectively inhibits pulmonary vasodilator responses to acetylcholine and bradykinin. J Appl Physiol (1985), 71(5), 2026–2031. https://doi.org/10.1152/jappl.1991.71.5.2026
McMahon, T. J., J. S. Hood, J. A. Bellan, and P. J. Kadowitz. “N omega-nitro-L-arginine methyl ester selectively inhibits pulmonary vasodilator responses to acetylcholine and bradykinin.J Appl Physiol (1985) 71, no. 5 (November 1991): 2026–31. https://doi.org/10.1152/jappl.1991.71.5.2026.
McMahon TJ, Hood JS, Bellan JA, Kadowitz PJ. N omega-nitro-L-arginine methyl ester selectively inhibits pulmonary vasodilator responses to acetylcholine and bradykinin. J Appl Physiol (1985). 1991 Nov;71(5):2026–31.
McMahon, T. J., et al. “N omega-nitro-L-arginine methyl ester selectively inhibits pulmonary vasodilator responses to acetylcholine and bradykinin.J Appl Physiol (1985), vol. 71, no. 5, Nov. 1991, pp. 2026–31. Pubmed, doi:10.1152/jappl.1991.71.5.2026.
McMahon TJ, Hood JS, Bellan JA, Kadowitz PJ. N omega-nitro-L-arginine methyl ester selectively inhibits pulmonary vasodilator responses to acetylcholine and bradykinin. J Appl Physiol (1985). 1991 Nov;71(5):2026–2031.

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

November 1991

Volume

71

Issue

5

Start / End Page

2026 / 2031

Location

United States

Related Subject Headings

  • Vasodilation
  • Pulmonary Circulation
  • Physiology
  • Nitroprusside
  • Nitric Oxide
  • NG-Nitroarginine Methyl Ester
  • Male
  • Isoproterenol
  • Female
  • Cyclic GMP