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Role of K+ATP channels and EDRF in reactive hyperemia in the hindquarters vascular bed of cats.

Publication ,  Journal Article
Minkes, RK; Santiago, JA; McMahon, TJ; Kadowitz, PJ
Published in: Am J Physiol
November 1995

The mechanism underlying reactive hyperemia was investigated in the feline hindquarters vascular bed under natural- and constant-flow conditions. A 30-s occlusion of the distal aorta produced a marked hyperemic increase in distal aortic blood flow that was attenuated by the ATP-sensitive K+ (K+ATP) channel blocking agent, glibenclamide. When blood flow to the hindquarters vascular bed was held constant with a pump, interruption of blood flow for 5- to 90-s periods produced reactive vasodilator responses that increased in magnitude and duration as the period of ischemia increased. The magnitude and duration of the reactive vasodilator responses were reduced by K+ATP channel antagonists and an inhibitor of nitric oxide synthase, whereas indomethacin had no significant effect. In the pulmonary vascular bed, under constant-flow, elevated tone conditions, a 30-s period of ischemia produced a small reactive vasodilator response and a larger secondary vasoconstrictor response. The present data suggest that reactive hyperemia in the hindquarters vascular bed is mediated by the opening of K+ATP channels and nitric oxide release and that the reactive hyperemic response is not pronounced in the pulmonary circulation.

Duke Scholars

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

November 1995

Volume

269

Issue

5 Pt 2

Start / End Page

H1704 / H1712

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Vasodilation
  • Regional Blood Flow
  • Pulmonary Circulation
  • Potassium Channels
  • Nitric Oxide Synthase
  • Nitric Oxide
  • NG-Nitroarginine Methyl Ester
  • Morpholines
  • Ischemia
 

Citation

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MLA
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Minkes, R. K., Santiago, J. A., McMahon, T. J., & Kadowitz, P. J. (1995). Role of K+ATP channels and EDRF in reactive hyperemia in the hindquarters vascular bed of cats. Am J Physiol, 269(5 Pt 2), H1704–H1712. https://doi.org/10.1152/ajpheart.1995.269.5.H1704
Minkes, R. K., J. A. Santiago, T. J. McMahon, and P. J. Kadowitz. “Role of K+ATP channels and EDRF in reactive hyperemia in the hindquarters vascular bed of cats.Am J Physiol 269, no. 5 Pt 2 (November 1995): H1704–12. https://doi.org/10.1152/ajpheart.1995.269.5.H1704.
Minkes RK, Santiago JA, McMahon TJ, Kadowitz PJ. Role of K+ATP channels and EDRF in reactive hyperemia in the hindquarters vascular bed of cats. Am J Physiol. 1995 Nov;269(5 Pt 2):H1704–12.
Minkes, R. K., et al. “Role of K+ATP channels and EDRF in reactive hyperemia in the hindquarters vascular bed of cats.Am J Physiol, vol. 269, no. 5 Pt 2, Nov. 1995, pp. H1704–12. Pubmed, doi:10.1152/ajpheart.1995.269.5.H1704.
Minkes RK, Santiago JA, McMahon TJ, Kadowitz PJ. Role of K+ATP channels and EDRF in reactive hyperemia in the hindquarters vascular bed of cats. Am J Physiol. 1995 Nov;269(5 Pt 2):H1704–H1712.

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

November 1995

Volume

269

Issue

5 Pt 2

Start / End Page

H1704 / H1712

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Vasodilation
  • Regional Blood Flow
  • Pulmonary Circulation
  • Potassium Channels
  • Nitric Oxide Synthase
  • Nitric Oxide
  • NG-Nitroarginine Methyl Ester
  • Morpholines
  • Ischemia