Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient.
Publication
, Journal Article
Stamler, JS; Jia, L; Eu, JP; McMahon, TJ; Demchenko, IT; Bonaventura, J; Gernert, K; Piantadosi, CA
Published in: Science
June 27, 1997
The binding of oxygen to heme irons in hemoglobin promotes the binding of nitric oxide (NO) to cysteinebeta93, forming S-nitrosohemoglobin. Deoxygenation is accompanied by an allosteric transition in S-nitrosohemoglobin [from the R (oxygenated) to the T (deoxygenated) structure] that releases the NO group. S-nitrosohemoglobin contracts blood vessels and decreases cerebral perfusion in the R structure and relaxes vessels to improve blood flow in the T structure. By thus sensing the physiological oxygen gradient in tissues, hemoglobin exploits conformation-associated changes in the position of cysteinebeta93 SNO to bring local blood flow into line with oxygen requirements.
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Published In
Science
DOI
ISSN
0036-8075
Publication Date
June 27, 1997
Volume
276
Issue
5321
Start / End Page
2034 / 2037
Location
United States
Related Subject Headings
- S-Nitrosothiols
- Rats, Sprague-Dawley
- Rats
- Protein Conformation
- Oxyhemoglobins
- Oxygen
- Nitroso Compounds
- Nitric Oxide
- Models, Molecular
- Mercaptoethanol
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ICMJE
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Stamler, J. S., Jia, L., Eu, J. P., McMahon, T. J., Demchenko, I. T., Bonaventura, J., … Piantadosi, C. A. (1997). Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science, 276(5321), 2034–2037. https://doi.org/10.1126/science.276.5321.2034
Stamler, J. S., L. Jia, J. P. Eu, T. J. McMahon, I. T. Demchenko, J. Bonaventura, K. Gernert, and C. A. Piantadosi. “Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient.” Science 276, no. 5321 (June 27, 1997): 2034–37. https://doi.org/10.1126/science.276.5321.2034.
Stamler JS, Jia L, Eu JP, McMahon TJ, Demchenko IT, Bonaventura J, et al. Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science. 1997 Jun 27;276(5321):2034–7.
Stamler, J. S., et al. “Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient.” Science, vol. 276, no. 5321, June 1997, pp. 2034–37. Pubmed, doi:10.1126/science.276.5321.2034.
Stamler JS, Jia L, Eu JP, McMahon TJ, Demchenko IT, Bonaventura J, Gernert K, Piantadosi CA. Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science. 1997 Jun 27;276(5321):2034–2037.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
June 27, 1997
Volume
276
Issue
5321
Start / End Page
2034 / 2037
Location
United States
Related Subject Headings
- S-Nitrosothiols
- Rats, Sprague-Dawley
- Rats
- Protein Conformation
- Oxyhemoglobins
- Oxygen
- Nitroso Compounds
- Nitric Oxide
- Models, Molecular
- Mercaptoethanol