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Transport and peripheral bioactivities of nitrogen oxides carried by red blood cell hemoglobin: role in oxygen delivery.

Publication ,  Journal Article
Sonveaux, P; Lobysheva, II; Feron, O; McMahon, TJ
Published in: Physiology (Bethesda)
April 2007

The biology of NO (nitric oxide) is poorly explained by the activity of the free radical NO ((.)NO) itself. Although (.)NO acts in an autocrine and paracrine manner, it is also in chemical equilibrium with other NO species that constitute stable stores of NO bioactivity. Among these species, S-nitrosylated hemoglobin (S-nitrosohemoglobin; SNO-Hb) is an evolved transducer of NO bioactivity that acts in a responsive and exquisitely regulated manner to control cardiopulmonary and vascular homeostasis. In SNO-Hb, O(2) sensing is dynamically coupled to formation and release of vasodilating SNOs, endowing the red blood cell (RBC) with the capacity to regulate its own principal function, O(2) delivery, via regulation of blood flow. Analogous, physiological actions of RBC SNO-Hb also contribute to central nervous responses to blood hypoxia, the uptake of O(2) from the lung to blood, and baroreceptor-mediated control of the systemic flow of blood. Dysregulation of the formation, export, or actions of RBC-derived SNOs has been implicated in human diseases including sepsis, sickle cell anemia, pulmonary arterial hypertension, and diabetes mellitus. Delivery of SNOs by the RBC can be harnessed for therapeutic gain, and early results support the logic of this approach in the treatment of diseases as varied as cancer and neonatal pulmonary hypertension.

Duke Scholars

Published In

Physiology (Bethesda)

DOI

ISSN

1548-9213

Publication Date

April 2007

Volume

22

Start / End Page

97 / 112

Location

United States

Related Subject Headings

  • Signal Transduction
  • Pressoreceptors
  • Physiology
  • Oxygen
  • Nitrogen Oxides
  • Lung
  • Hypoxia
  • Humans
  • Hemoglobins
  • Erythrocytes
 

Citation

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Sonveaux, P., Lobysheva, I. I., Feron, O., & McMahon, T. J. (2007). Transport and peripheral bioactivities of nitrogen oxides carried by red blood cell hemoglobin: role in oxygen delivery. Physiology (Bethesda), 22, 97–112. https://doi.org/10.1152/physiol.00042.2006
Sonveaux, Pierre, Irina I. Lobysheva, Olivier Feron, and Timothy J. McMahon. “Transport and peripheral bioactivities of nitrogen oxides carried by red blood cell hemoglobin: role in oxygen delivery.Physiology (Bethesda) 22 (April 2007): 97–112. https://doi.org/10.1152/physiol.00042.2006.
Sonveaux P, Lobysheva II, Feron O, McMahon TJ. Transport and peripheral bioactivities of nitrogen oxides carried by red blood cell hemoglobin: role in oxygen delivery. Physiology (Bethesda). 2007 Apr;22:97–112.
Sonveaux, Pierre, et al. “Transport and peripheral bioactivities of nitrogen oxides carried by red blood cell hemoglobin: role in oxygen delivery.Physiology (Bethesda), vol. 22, Apr. 2007, pp. 97–112. Pubmed, doi:10.1152/physiol.00042.2006.
Sonveaux P, Lobysheva II, Feron O, McMahon TJ. Transport and peripheral bioactivities of nitrogen oxides carried by red blood cell hemoglobin: role in oxygen delivery. Physiology (Bethesda). 2007 Apr;22:97–112.

Published In

Physiology (Bethesda)

DOI

ISSN

1548-9213

Publication Date

April 2007

Volume

22

Start / End Page

97 / 112

Location

United States

Related Subject Headings

  • Signal Transduction
  • Pressoreceptors
  • Physiology
  • Oxygen
  • Nitrogen Oxides
  • Lung
  • Hypoxia
  • Humans
  • Hemoglobins
  • Erythrocytes