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Intraischemic nitrous oxide alters neither neurologic nor histologic outcome: a comparison with dizocilpine.

Publication ,  Journal Article
Yokoo, N; Sheng, H; Mixco, J; Homi, HM; Pearlstein, RD; Warner, DS
Published in: Anesth Analg
September 2004

N-Methyl-D-aspartate receptor antagonism contributes to the anesthetic action of nitrous oxide (N(2)O). We examined the effects of the N-methyl-D-aspartate antagonists N(2)O and dizocilpine on outcome from filament occlusion of the middle cerebral artery (MCAO). Rats breathed 70% nitrogen/30% oxygen or 70% N(2)O/30% oxygen during MCAO. A third group breathed 70% nitrogen/30% oxygen and was given dizocilpine (0.25 mg/kg IV). After 75 min of MCAO, the rats recovered for 3 or 14 days. Pericranial temperature was maintained at 37.5 degrees C +/- 0.2 degrees C during ischemia and for 20 h postischemia. N(2)O did not alter neurologic scores at 3 days (N(2)O, 21 +/- 6; nitrogen, 22 +/- 8; P = 0.95; 0 = normal; 48 = maximal deficit; mean +/- sd; n = 15) or 14 days (N(2)O, 13 +/- 6; nitrogen, 12 +/- 6; P = 0.93; n = 15-16) postischemia. N(2)O had no effect on infarct size at 3 days (N(2)O, 162 +/- 45 mm(3); nitrogen, 162 +/- 61 mm(3); P > 0.99) or 14 days (N(2)O, 147 +/- 56 mm(3); nitrogen, 151 +/- 62 mm(3); P = 0.99) postischemia. Dizocilpine treatment caused smaller infarcts (3 days: 66 +/- 49 mm(3), P < 0.0001 versus nitrogen; 14 days: 84 +/- 50 mm(3), P < 0.006 versus nitrogen) and reduced the neurologic deficit (3 days: 10 +/- 10, P = 0.002 versus nitrogen; 14 days: 6 +/- 7, P = 0.006 versus nitrogen). N(2)O (70%) had no effect on either behavioral or histologic outcome from transient focal cerebral ischemia when compared with results in rats breathing 70% nitrogen. These results indicate that normobaric N(2)O does not alter the response of rat brain to a focal ischemic insult.

Duke Scholars

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

September 2004

Volume

99

Issue

3

Start / End Page

896 / 903

Location

United States

Related Subject Headings

  • Regression Analysis
  • Receptors, N-Methyl-D-Aspartate
  • Rats, Wistar
  • Rats
  • Nitrous Oxide
  • Male
  • Ischemic Attack, Transient
  • Intubation, Intratracheal
  • Dizocilpine Maleate
  • Blood Pressure
 

Citation

APA
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ICMJE
MLA
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Yokoo, N., Sheng, H., Mixco, J., Homi, H. M., Pearlstein, R. D., & Warner, D. S. (2004). Intraischemic nitrous oxide alters neither neurologic nor histologic outcome: a comparison with dizocilpine. Anesth Analg, 99(3), 896–903. https://doi.org/10.1213/01.ANE.0000132973.32387.8B
Yokoo, Noriko, Huaxin Sheng, Javier Mixco, H Mayumi Homi, Robert D. Pearlstein, and David S. Warner. “Intraischemic nitrous oxide alters neither neurologic nor histologic outcome: a comparison with dizocilpine.Anesth Analg 99, no. 3 (September 2004): 896–903. https://doi.org/10.1213/01.ANE.0000132973.32387.8B.
Yokoo N, Sheng H, Mixco J, Homi HM, Pearlstein RD, Warner DS. Intraischemic nitrous oxide alters neither neurologic nor histologic outcome: a comparison with dizocilpine. Anesth Analg. 2004 Sep;99(3):896–903.
Yokoo, Noriko, et al. “Intraischemic nitrous oxide alters neither neurologic nor histologic outcome: a comparison with dizocilpine.Anesth Analg, vol. 99, no. 3, Sept. 2004, pp. 896–903. Pubmed, doi:10.1213/01.ANE.0000132973.32387.8B.
Yokoo N, Sheng H, Mixco J, Homi HM, Pearlstein RD, Warner DS. Intraischemic nitrous oxide alters neither neurologic nor histologic outcome: a comparison with dizocilpine. Anesth Analg. 2004 Sep;99(3):896–903.

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

September 2004

Volume

99

Issue

3

Start / End Page

896 / 903

Location

United States

Related Subject Headings

  • Regression Analysis
  • Receptors, N-Methyl-D-Aspartate
  • Rats, Wistar
  • Rats
  • Nitrous Oxide
  • Male
  • Ischemic Attack, Transient
  • Intubation, Intratracheal
  • Dizocilpine Maleate
  • Blood Pressure