Oxidants, antioxidants and the ischemic brain.

Published

Journal Article (Review)

Despite numerous defenses, the brain is vulnerable to oxidative stress resulting from ischemia/reperfusion. Excitotoxic stimulation of superoxide and nitric oxide production leads to formation of highly reactive products, including peroxynitrite and hydroxyl radical, which are capable of damaging lipids, proteins and DNA. Use of transgenic mutants and selective pharmacological antioxidants has greatly increased understanding of the complex interplay between substrate deprivation and ischemic outcome. Recent evidence that reactive oxygen/nitrogen species play a critical role in initiation of apoptosis, mitochondrial permeability transition and poly(ADP-ribose) polymerase activation provides additional mechanisms for oxidative damage and new targets for post-ischemic therapeutic intervention. Because oxidative stress involves multiple post-ischemic cascades leading to cell death, effective prevention/treatment of ischemic brain injury is likely to require intervention at multiple effect sites.

Full Text

Duke Authors

Cited Authors

  • Warner, DS; Sheng, H; Batinić-Haberle, I

Published Date

  • August 2004

Published In

Volume / Issue

  • 207 / Pt 18

Start / End Page

  • 3221 - 3231

PubMed ID

  • 15299043

Pubmed Central ID

  • 15299043

International Standard Serial Number (ISSN)

  • 0022-0949

Digital Object Identifier (DOI)

  • 10.1242/jeb.01022

Language

  • eng

Conference Location

  • England