The influence of different concentrations of volatile anesthetics on the threshold for cortical spreading depression in rats.


Journal Article

We studied the influence of halothane and isoflurane on the electrical threshold for triggering spreading depression (SD) in rats. While the N-methyl-D-aspartate (NMDA) antagonist ketamine dramatically increased the triggering threshold (and blocked propagation), neither volatile agent had any dose-related effect. High doses of both agents slightly slowed SD propagation rate. These results indicate that volatile agents in typical anesthetic doses can be used in studies of SD in rats, and also suggest that these agents have little effect on NMDA receptor-mediated neurotransmission.

Full Text

Duke Authors

Cited Authors

  • Verhaegen, M; Todd, MM; Warner, DS

Published Date

  • May 22, 1992

Published In

Volume / Issue

  • 581 / 1

Start / End Page

  • 153 - 155

PubMed ID

  • 1498665

Pubmed Central ID

  • 1498665

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(92)90355-d


  • eng

Conference Location

  • Netherlands