Glycine antagonism does not block ischemic spontaneous depolarization in the rat.
Publication
, Journal Article
Takaoka, S; Bart, RD; Pearlstein, RD; Warner, DS
Published in: Neuroreport
March 24, 1997
This study examined the effect of glycine recognition site antagonism (ACEA 1021) on the incidence of spontaneous depolarizations in the penumbra of a focal ischemic lesion. Rats were administered either vehicle (n = 7), ACEA 1021 (n = 7) or dizocilpine (n = 5) and then underwent 90 min middle cerebral artery occlusion. The cortical direct current (DC) potential was recorded. During ischemia, 7 +/- 3 DC shifts occurred in the vehicle group. ACEA 1021 did not reduce this frequency (7 +/- 2 DC shifts) although dizocilpine did (1 +/- 1 DC shifts; p = 0.02). The previously demonstrated neuroprotective property of ACEA 1021 during focal cerebral ischemia cannot be attributed to reduction of spontaneous depolarization in the ischemic penumbra.
Duke Scholars
Published In
Neuroreport
DOI
ISSN
0959-4965
Publication Date
March 24, 1997
Volume
8
Issue
5
Start / End Page
1139 / 1142
Location
England
Related Subject Headings
- Receptors, Glycine
- Rats, Wistar
- Rats
- Quinoxalines
- Neuroprotective Agents
- Neurology & Neurosurgery
- Membrane Potentials
- Male
- Ischemic Attack, Transient
- Excitatory Amino Acid Antagonists
Citation
APA
Chicago
ICMJE
MLA
NLM
Takaoka, S., Bart, R. D., Pearlstein, R. D., & Warner, D. S. (1997). Glycine antagonism does not block ischemic spontaneous depolarization in the rat. Neuroreport, 8(5), 1139–1142. https://doi.org/10.1097/00001756-199703240-00016
Takaoka, S., R. D. Bart, R. D. Pearlstein, and D. S. Warner. “Glycine antagonism does not block ischemic spontaneous depolarization in the rat.” Neuroreport 8, no. 5 (March 24, 1997): 1139–42. https://doi.org/10.1097/00001756-199703240-00016.
Takaoka S, Bart RD, Pearlstein RD, Warner DS. Glycine antagonism does not block ischemic spontaneous depolarization in the rat. Neuroreport. 1997 Mar 24;8(5):1139–42.
Takaoka, S., et al. “Glycine antagonism does not block ischemic spontaneous depolarization in the rat.” Neuroreport, vol. 8, no. 5, Mar. 1997, pp. 1139–42. Pubmed, doi:10.1097/00001756-199703240-00016.
Takaoka S, Bart RD, Pearlstein RD, Warner DS. Glycine antagonism does not block ischemic spontaneous depolarization in the rat. Neuroreport. 1997 Mar 24;8(5):1139–1142.
Published In
Neuroreport
DOI
ISSN
0959-4965
Publication Date
March 24, 1997
Volume
8
Issue
5
Start / End Page
1139 / 1142
Location
England
Related Subject Headings
- Receptors, Glycine
- Rats, Wistar
- Rats
- Quinoxalines
- Neuroprotective Agents
- Neurology & Neurosurgery
- Membrane Potentials
- Male
- Ischemic Attack, Transient
- Excitatory Amino Acid Antagonists