Glycine antagonism does not block ischemic spontaneous depolarization in the rat.

Published

Journal Article

This study examined the effect of glycine recognition site antagonism (ACEA 1021) on the incidence of spontaneous depolarizations in the penumbra of a focal ischemic lesion. Rats were administered either vehicle (n = 7), ACEA 1021 (n = 7) or dizocilpine (n = 5) and then underwent 90 min middle cerebral artery occlusion. The cortical direct current (DC) potential was recorded. During ischemia, 7 +/- 3 DC shifts occurred in the vehicle group. ACEA 1021 did not reduce this frequency (7 +/- 2 DC shifts) although dizocilpine did (1 +/- 1 DC shifts; p = 0.02). The previously demonstrated neuroprotective property of ACEA 1021 during focal cerebral ischemia cannot be attributed to reduction of spontaneous depolarization in the ischemic penumbra.

Full Text

Duke Authors

Cited Authors

  • Takaoka, S; Bart, RD; Pearlstein, RD; Warner, DS

Published Date

  • March 1997

Published In

Volume / Issue

  • 8 / 5

Start / End Page

  • 1139 - 1142

PubMed ID

  • 9175101

Pubmed Central ID

  • 9175101

Electronic International Standard Serial Number (EISSN)

  • 1473-558X

International Standard Serial Number (ISSN)

  • 0959-4965

Digital Object Identifier (DOI)

  • 10.1097/00001756-199703240-00016

Language

  • eng