Forebrain ischemia induces selective behavioral impairments associated with hippocampal injury in rats.

Journal Article (Journal Article)

Two groups of rats were tested on a variety of motor and cognitive tasks after either 10 minutes of two-vessel occlusion forebrain ischemia (n = 8) or sham operative procedures (n = 6). Histological injury was absent in the sham-operated group. In the ischemic group, hippocampal injury was restricted to field CA1, while damage in the neocortex and caudoputamen was sparse. Motor tests performed on postoperative days 18 and 28 revealed no significant differences between the ischemic and sham-operated groups. Retention performance of a radial maze discrimination task was impaired, with a significant but transient increase in both working and reference memory errors. Passive avoidance acquisition and retention were not significantly affected, although conclusions concerning the utility of this task must be reserved because of variability in the behavior of the sham-operated rats. Morris maze spatial navigation (place learning) and open-field activity were insensitive to treatment group. These functional results are consistent with the observed histological injury and what is known about hippocampal injury and behavior, and they provide further guidance for the development of neurological assays appropriate for discriminating outcome from forebrain ischemia in rats.

Full Text

Duke Authors

Cited Authors

  • Gionet, TX; Thomas, JD; Warner, DS; Goodlett, CR; Wasserman, EA; West, JR

Published Date

  • August 1991

Published In

Volume / Issue

  • 22 / 8

Start / End Page

  • 1040 - 1047

PubMed ID

  • 1866751

Pubmed Central ID

  • 1866751

International Standard Serial Number (ISSN)

  • 0039-2499

Digital Object Identifier (DOI)

  • 10.1161/01.str.22.8.1040


  • eng

Conference Location

  • United States