Use of sodium chromate Cr51 in diagnosing childhood idiopathic pulmonary hemosiderosis.
Journal Article (Journal Article)
The diagnosis of idiopathic pulmonary hemosiderosis (IPH) may be elusive. A 6-year-old boy had microcytic hypochromic anemia and a hemolytic component. Hemosiderin-laden macrophages were not found in the gastric aspirate. He had no pulmonary signs or symptoms. Extensive hematologic and roentgenologic investigations failed to reveal the cause of the anemia. Quantitative serial scintigraphic scanning showed significant (35%) pulmonary sequestration of autologous erythrocytes labeled with sodium chromate Cr51. The half-life of the RBCs was moderately decreased (half-life, 15 days; normal, 25 to 35 days). An open-lung biopsy specimen confirmed the diagnosis of IPH. A diagnosis of IPH should be considered when children have iron deficiency anemia and pulmonary signs or symptoms. Organ sequestration studies may be helpful in equivocal cases.
Full Text
Duke Authors
Cited Authors
- Kurzweil, PR; Miller, DR; Freeman, JE; Reiman, RE; Mayer, K
Published Date
- August 1984
Published In
Volume / Issue
- 138 / 8
Start / End Page
- 746 - 748
PubMed ID
- 6741890
International Standard Serial Number (ISSN)
- 0002-922X
Digital Object Identifier (DOI)
- 10.1001/archpedi.1984.02140460038012
Language
- eng
Conference Location
- United States