Use of sodium chromate Cr51 in diagnosing childhood idiopathic pulmonary hemosiderosis.

Journal Article (Journal Article)

The diagnosis of idiopathic pulmonary hemosiderosis (IPH) may be elusive. A 6-year-old boy had microcytic hypochromic anemia and a hemolytic component. Hemosiderin-laden macrophages were not found in the gastric aspirate. He had no pulmonary signs or symptoms. Extensive hematologic and roentgenologic investigations failed to reveal the cause of the anemia. Quantitative serial scintigraphic scanning showed significant (35%) pulmonary sequestration of autologous erythrocytes labeled with sodium chromate Cr51. The half-life of the RBCs was moderately decreased (half-life, 15 days; normal, 25 to 35 days). An open-lung biopsy specimen confirmed the diagnosis of IPH. A diagnosis of IPH should be considered when children have iron deficiency anemia and pulmonary signs or symptoms. Organ sequestration studies may be helpful in equivocal cases.

Full Text

Duke Authors

Cited Authors

  • Kurzweil, PR; Miller, DR; Freeman, JE; Reiman, RE; Mayer, K

Published Date

  • August 1984

Published In

Volume / Issue

  • 138 / 8

Start / End Page

  • 746 - 748

PubMed ID

  • 6741890

International Standard Serial Number (ISSN)

  • 0002-922X

Digital Object Identifier (DOI)

  • 10.1001/archpedi.1984.02140460038012


  • eng

Conference Location

  • United States