Imaging of brain tumors after administration of L-(N-13)glutamate: concise communication.

Journal Article

Cyclotron-produced L-(N-13)glutamate was used to visualize malignant intracranial tumors in 12 pediatric patients who had evidence of recurrent disease as documented by computed transaxial tomography (TCT). Imaging was performed using a rectilinear scanner, gamma camera, or a positron-emission tomograph (PET). The results indicate that N-13 is rapidly taken up by a majority of brain tumors following the administration of L-(N-13)glutamate, and that N-13 uptake is correlated with breakdown of the blood-brain barrier as demonstrated by contrast TCT or pertechnetate (Tc-99m) studies. The feasibility of using this agent in conjunction with PET is established.

Full Text

Duke Authors

Cited Authors

  • Reiman, RE; Benua, RS; Gelbard, AS; Allen, JC; Vomero, JJ; Laughlin, JS

Published Date

  • August 1982

Published In

Volume / Issue

  • 23 / 8

Start / End Page

  • 682 - 687

PubMed ID

  • 6125576

International Standard Serial Number (ISSN)

  • 0161-5505


  • eng

Conference Location

  • United States