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Imaging of brain tumors after administration of L-(N-13)glutamate: concise communication.

Publication ,  Journal Article
Reiman, RE; Benua, RS; Gelbard, AS; Allen, JC; Vomero, JJ; Laughlin, JS
Published in: J Nucl Med
August 1982

Cyclotron-produced L-(N-13)glutamate was used to visualize malignant intracranial tumors in 12 pediatric patients who had evidence of recurrent disease as documented by computed transaxial tomography (TCT). Imaging was performed using a rectilinear scanner, gamma camera, or a positron-emission tomograph (PET). The results indicate that N-13 is rapidly taken up by a majority of brain tumors following the administration of L-(N-13)glutamate, and that N-13 uptake is correlated with breakdown of the blood-brain barrier as demonstrated by contrast TCT or pertechnetate (Tc-99m) studies. The feasibility of using this agent in conjunction with PET is established.

Duke Scholars

Published In

J Nucl Med

ISSN

0161-5505

Publication Date

August 1982

Volume

23

Issue

8

Start / End Page

682 / 687

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Tomography, Emission-Computed
  • Technetium
  • Sodium Pertechnetate Tc 99m
  • Nuclear Medicine & Medical Imaging
  • Nitrogen Radioisotopes
  • Male
  • Humans
  • Glutamic Acid
  • Glutamates
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Reiman, R. E., Benua, R. S., Gelbard, A. S., Allen, J. C., Vomero, J. J., & Laughlin, J. S. (1982). Imaging of brain tumors after administration of L-(N-13)glutamate: concise communication. J Nucl Med, 23(8), 682–687.
Reiman, R. E., R. S. Benua, A. S. Gelbard, J. C. Allen, J. J. Vomero, and J. S. Laughlin. “Imaging of brain tumors after administration of L-(N-13)glutamate: concise communication.J Nucl Med 23, no. 8 (August 1982): 682–87.
Reiman RE, Benua RS, Gelbard AS, Allen JC, Vomero JJ, Laughlin JS. Imaging of brain tumors after administration of L-(N-13)glutamate: concise communication. J Nucl Med. 1982 Aug;23(8):682–7.
Reiman, R. E., et al. “Imaging of brain tumors after administration of L-(N-13)glutamate: concise communication.J Nucl Med, vol. 23, no. 8, Aug. 1982, pp. 682–87.
Reiman RE, Benua RS, Gelbard AS, Allen JC, Vomero JJ, Laughlin JS. Imaging of brain tumors after administration of L-(N-13)glutamate: concise communication. J Nucl Med. 1982 Aug;23(8):682–687.

Published In

J Nucl Med

ISSN

0161-5505

Publication Date

August 1982

Volume

23

Issue

8

Start / End Page

682 / 687

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Tomography, Emission-Computed
  • Technetium
  • Sodium Pertechnetate Tc 99m
  • Nuclear Medicine & Medical Imaging
  • Nitrogen Radioisotopes
  • Male
  • Humans
  • Glutamic Acid
  • Glutamates