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Quotient imaging with N-13 L-glutamate in osteogenic sarcoma: correlation with tumor viability.

Publication ,  Journal Article
Reiman, RE; Huvos, AG; Benua, RS; Rosen, G; Gelbard, AS; Laughlin, JS
Published in: Cancer
November 1, 1981

An investigation was performed to correlate the regional uptake of N-13 L-glutamate with histologic changes in tumor tissue in patients undergoing adjuvant chemotherapy for osteogenic sarcoma. A parametric image was produced by calculating the ratio of N-13 uptake in the tumor in a pixel-by-pixel fashion, using the presurgical scan as the numerator and the pretherapy scan as the denominator. The change in N-13 uptake in 2 x 2-cm regions of the tumor was compared with residual cell viability as determined by microscopic examination of multiple thin sections obtained from the surgical specimens. Regions that showed decreases in N-13 uptake of more than 30% were frequently associated with areas of highly necrotic tumor, and regions that showed increasing uptake were associated with high residual cell viability and incomplete response to chemotherapy.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

November 1, 1981

Volume

48

Issue

9

Start / End Page

1976 / 1981

Location

United States

Related Subject Headings

  • Osteosarcoma
  • Oncology & Carcinogenesis
  • Nitrogen Radioisotopes
  • Male
  • Humans
  • Glutamic Acid
  • Glutamates
  • Female
  • Child
  • Bone Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Reiman, R. E., Huvos, A. G., Benua, R. S., Rosen, G., Gelbard, A. S., & Laughlin, J. S. (1981). Quotient imaging with N-13 L-glutamate in osteogenic sarcoma: correlation with tumor viability. Cancer, 48(9), 1976–1981. https://doi.org/10.1002/1097-0142(19811101)48:9<1976::aid-cncr2820480912>3.0.co;2-x
Reiman, R. E., A. G. Huvos, R. S. Benua, G. Rosen, A. S. Gelbard, and J. S. Laughlin. “Quotient imaging with N-13 L-glutamate in osteogenic sarcoma: correlation with tumor viability.Cancer 48, no. 9 (November 1, 1981): 1976–81. https://doi.org/10.1002/1097-0142(19811101)48:9<1976::aid-cncr2820480912>3.0.co;2-x.
Reiman RE, Huvos AG, Benua RS, Rosen G, Gelbard AS, Laughlin JS. Quotient imaging with N-13 L-glutamate in osteogenic sarcoma: correlation with tumor viability. Cancer. 1981 Nov 1;48(9):1976–81.
Reiman, R. E., et al. “Quotient imaging with N-13 L-glutamate in osteogenic sarcoma: correlation with tumor viability.Cancer, vol. 48, no. 9, Nov. 1981, pp. 1976–81. Pubmed, doi:10.1002/1097-0142(19811101)48:9<1976::aid-cncr2820480912>3.0.co;2-x.
Reiman RE, Huvos AG, Benua RS, Rosen G, Gelbard AS, Laughlin JS. Quotient imaging with N-13 L-glutamate in osteogenic sarcoma: correlation with tumor viability. Cancer. 1981 Nov 1;48(9):1976–1981.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

November 1, 1981

Volume

48

Issue

9

Start / End Page

1976 / 1981

Location

United States

Related Subject Headings

  • Osteosarcoma
  • Oncology & Carcinogenesis
  • Nitrogen Radioisotopes
  • Male
  • Humans
  • Glutamic Acid
  • Glutamates
  • Female
  • Child
  • Bone Neoplasms