Imaging studies of patients with malignant fibrous histiocytoma using C-11-alpha-aminoisobutyric acid (AIB).

Journal Article (Journal Article)

Alpha-aminoisobutyric acid (AIB), a synthetic, nonmetabolized amino acid which is rapidly transported into viable cells by the A-type or alanine-preferring amino acid transport system, has been labeled with the short-lived, positron-emitting radionuclide carbon-11. Carbon-11 labeled AIB is currently being evaluated as a tumor imaging agent for in vivo amino acid transport studies in patients with cancer. In this study, C-11 AIB was used to image two patients with malignant fibrous histiocytoma (MFH), a pleomorphic sarcoma. Following intravenous administration of C-11 AIB, tumors in the distal femur of one patient and in the anterior chest wall of another patient were well visualized using high energy gamma scintigraphy. Since therapy may alter the accumulation of amino acids in tumor tissue, studies using C-11 AIB in patients with MFH before and after chemotherapy are in progress.

Full Text

Duke Authors

Cited Authors

  • Schmall, B; Conti, PS; Bigler, RE; Zanzonico, PB; Reiman, RE; Benua, RS; Yeh, SD; Dahl, JR; Lee, R; Laughlin, JS

Published Date

  • January 1987

Published In

Volume / Issue

  • 12 / 1

Start / End Page

  • 22 - 26

PubMed ID

  • 3028690

International Standard Serial Number (ISSN)

  • 0363-9762

Digital Object Identifier (DOI)

  • 10.1097/00003072-198701000-00005


  • eng

Conference Location

  • United States