Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia.


Journal Article

Changes in the expression of glial glutamate transporters (GLAST and GLT-1) were examined in the spinal cord of rats with chemotherapy (taxol)-induced mechanical hyperalgesia. Immunohistochemical studies show that the expression of both GLAST and GLT-1 in the L4-L5 spinal dorsal horn is decreased by 24% (P<0.001) and 23% (P<0.001), respectively, in rats with taxol-induced hyperalgesia as compared with those in control rats. These changes were further confirmed using an enzyme-linked immunosorbent assay that confirmed downregulation of GLAST by 36% (P<0.05) and GLT-1 by 18% (P<0.05) in the L4-L5 spinal cord of taxol-treated rats. These data indicate that downregulation of glutamate transporters may contribute to the development of hyperalgesia induced by taxol and suggest that glutamate transporters may be a new target for treatment of pain.

Full Text

Cited Authors

  • Weng, H-R; Aravindan, N; Cata, JP; Chen, J-H; Shaw, ADS; Dougherty, PM

Published Date

  • September 23, 2005

Published In

Volume / Issue

  • 386 / 1

Start / End Page

  • 18 - 22

PubMed ID

  • 15975716

Pubmed Central ID

  • 15975716

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/j.neulet.2005.05.049


  • eng

Conference Location

  • Ireland