Synthesis of brasilibactin A and confirmation of absolute configuration of β-hydroxy acid fragment
Publication
, Journal Article
Ying, Y; Hong, J
Published in: Tetrahedron Letters
November 12, 2007
A synthesis of brasilibactin A, a cytotoxic siderophore from the actinomycete of Nocardia brasiliensis, and three unnatural diastereomers of the natural product is described. Four possible diastereomers of the β-hydroxy acid fragment were prepared via asymmetric aldol reactions and used to synthesize brasilibactin A and its diastereomers. Careful analysis of 1H NMR data confirmed that brasilibactin A possesses the 17S,18R absolute stereochemistry. © 2007 Elsevier Ltd. All rights reserved.
Duke Scholars
Published In
Tetrahedron Letters
DOI
ISSN
0040-4039
Publication Date
November 12, 2007
Volume
48
Issue
46
Start / End Page
8104 / 8107
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Ying, Y., & Hong, J. (2007). Synthesis of brasilibactin A and confirmation of absolute configuration of β-hydroxy acid fragment. Tetrahedron Letters, 48(46), 8104–8107. https://doi.org/10.1016/j.tetlet.2007.09.112
Ying, Y., and J. Hong. “Synthesis of brasilibactin A and confirmation of absolute configuration of β-hydroxy acid fragment.” Tetrahedron Letters 48, no. 46 (November 12, 2007): 8104–7. https://doi.org/10.1016/j.tetlet.2007.09.112.
Ying Y, Hong J. Synthesis of brasilibactin A and confirmation of absolute configuration of β-hydroxy acid fragment. Tetrahedron Letters. 2007 Nov 12;48(46):8104–7.
Ying, Y., and J. Hong. “Synthesis of brasilibactin A and confirmation of absolute configuration of β-hydroxy acid fragment.” Tetrahedron Letters, vol. 48, no. 46, Nov. 2007, pp. 8104–07. Scopus, doi:10.1016/j.tetlet.2007.09.112.
Ying Y, Hong J. Synthesis of brasilibactin A and confirmation of absolute configuration of β-hydroxy acid fragment. Tetrahedron Letters. 2007 Nov 12;48(46):8104–8107.
Published In
Tetrahedron Letters
DOI
ISSN
0040-4039
Publication Date
November 12, 2007
Volume
48
Issue
46
Start / End Page
8104 / 8107
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry