Synthesis of brasilibactin A and confirmation of absolute configuration of β-hydroxy acid fragment

Journal Article (Journal Article)

A synthesis of brasilibactin A, a cytotoxic siderophore from the actinomycete of Nocardia brasiliensis, and three unnatural diastereomers of the natural product is described. Four possible diastereomers of the β-hydroxy acid fragment were prepared via asymmetric aldol reactions and used to synthesize brasilibactin A and its diastereomers. Careful analysis of 1H NMR data confirmed that brasilibactin A possesses the 17S,18R absolute stereochemistry. © 2007 Elsevier Ltd. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Ying, Y; Hong, J

Published Date

  • November 12, 2007

Published In

Volume / Issue

  • 48 / 46

Start / End Page

  • 8104 - 8107

International Standard Serial Number (ISSN)

  • 0040-4039

Digital Object Identifier (DOI)

  • 10.1016/j.tetlet.2007.09.112

Citation Source

  • Scopus