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Postcardiac surgery complications: association of acute renal dysfunction and atrial fibrillation.

Publication ,  Journal Article
Albahrani, MJ; Swaminathan, M; Phillips-Bute, B; Smith, PK; Newman, MF; Mathew, JP; Stafford-Smith, M
Published in: Anesth Analg
March 2003

UNLABELLED: Postoperative creatinine increase is associated with adverse outcome after cardiac surgery. Although postoperative stroke and renal dysfunction are associated after cardiac surgery, suggesting a common systemic insult, a similar assessment of atrial fibrillation and renal dysfunction has not been performed. Therefore, we tested the hypothesis that patients with new-onset atrial fibrillation complicating coronary bypass surgery have a greater postoperative creatinine increase. Data were obtained for 453 elective coronary bypass surgery patients with no history of atrial fibrillation. Multivariate regression analyses of factors associated with peak fractional change in creatinine demonstrated a two-way interaction between age and atrial fibrillation (variable estimate, -1.1; P = 0.002). Similar results were obtained in a secondary multivariate model analyzing factors associated with peak postoperative creatinine (variable estimate, -0.01; P = 0.04). We confirmed our hypothesis that patients with new-onset atrial fibrillation are more likely to have acute renal dysfunction after cardiac surgery. The association of atrial fibrillation and creatinine increase diminishes with advancing age. These data are consistent with a common pathophysiology that contributes in an age-dependent fashion to the etiology of both acute renal dysfunction and atrial fibrillation after coronary bypass surgery. IMPLICATIONS: We found an independent association between new-onset atrial fibrillation and postoperative creatinine increase that is influenced by age. The degree to which atrial fibrillation is associated with postoperative creatinine increase diminishes with advancing age. This interaction suggests that a common etiology for these two complications may be more important in younger patients.

Duke Scholars

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

March 2003

Volume

96

Issue

3

Start / End Page

637 / 643

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Risk Factors
  • Prospective Studies
  • Postoperative Complications
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Linear Models
  • Kidney Function Tests
 

Citation

APA
Chicago
ICMJE
MLA
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Albahrani, M. J., Swaminathan, M., Phillips-Bute, B., Smith, P. K., Newman, M. F., Mathew, J. P., & Stafford-Smith, M. (2003). Postcardiac surgery complications: association of acute renal dysfunction and atrial fibrillation. Anesth Analg, 96(3), 637–643. https://doi.org/10.1213/01.ANE.0000047886.81598.2C
Albahrani, Maher J., Madhav Swaminathan, Barbara Phillips-Bute, Peter K. Smith, Mark F. Newman, Joseph P. Mathew, and Mark Stafford-Smith. “Postcardiac surgery complications: association of acute renal dysfunction and atrial fibrillation.Anesth Analg 96, no. 3 (March 2003): 637–43. https://doi.org/10.1213/01.ANE.0000047886.81598.2C.
Albahrani MJ, Swaminathan M, Phillips-Bute B, Smith PK, Newman MF, Mathew JP, et al. Postcardiac surgery complications: association of acute renal dysfunction and atrial fibrillation. Anesth Analg. 2003 Mar;96(3):637–43.
Albahrani, Maher J., et al. “Postcardiac surgery complications: association of acute renal dysfunction and atrial fibrillation.Anesth Analg, vol. 96, no. 3, Mar. 2003, pp. 637–43. Pubmed, doi:10.1213/01.ANE.0000047886.81598.2C.
Albahrani MJ, Swaminathan M, Phillips-Bute B, Smith PK, Newman MF, Mathew JP, Stafford-Smith M. Postcardiac surgery complications: association of acute renal dysfunction and atrial fibrillation. Anesth Analg. 2003 Mar;96(3):637–643.

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

March 2003

Volume

96

Issue

3

Start / End Page

637 / 643

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Risk Factors
  • Prospective Studies
  • Postoperative Complications
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Linear Models
  • Kidney Function Tests