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Report of a substudy on warm versus cold cardiopulmonary bypass: changes in creatinine clearance.

Publication ,  Journal Article
Swaminathan, M; East, C; Phillips-Bute, B; Newman, MF; Reves, JG; Smith, PK; Stafford-Smith, M
Published in: Ann Thorac Surg
November 2001

BACKGROUND: Renal dysfunction remains a major complication of cardiac operations. There is concern regarding the possibility of increased renal injury during warm cardiopulmonary bypass (CPB). Therefore, we tested the hypothesis that warm CPB is associated with a greater reduction in creatinine clearance after cardiac surgery than hypothermic CPB. METHODS: We randomly assigned 300 patients who had elective coronary artery bypass grafting to warm (35.5 to 36.5 degrees C) or cold (28 degrees C to 30 degrees C) CPB. Preoperative and peak postoperative serum creatinine values were recorded. Creatinine clearance was estimated using the Cockroft Gault equation. Univariate and multivariable analyses were performed to test the association of CPB temperature and perioperative change in creatinine clearance. RESULTS: Demographic variables were similar between groups. Multivariable analysis did not confirm an association between temperature and change in creatinine clearance (p = 0.87). CONCLUSIONS: We did not confirm an association between warm CPB and increased renal dysfunction after cardiac operations compared with hypothermic CPB.

Duke Scholars

Published In

Ann Thorac Surg

DOI

ISSN

0003-4975

Publication Date

November 2001

Volume

72

Issue

5

Start / End Page

1603 / 1609

Location

Netherlands

Related Subject Headings

  • Temperature
  • Respiratory System
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Female
  • Creatinine
  • Cardiopulmonary Bypass
  • Aged
 

Citation

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Swaminathan, M., East, C., Phillips-Bute, B., Newman, M. F., Reves, J. G., Smith, P. K., & Stafford-Smith, M. (2001). Report of a substudy on warm versus cold cardiopulmonary bypass: changes in creatinine clearance. Ann Thorac Surg, 72(5), 1603–1609. https://doi.org/10.1016/s0003-4975(01)03223-4
Swaminathan, M., C. East, B. Phillips-Bute, M. F. Newman, J. G. Reves, P. K. Smith, and M. Stafford-Smith. “Report of a substudy on warm versus cold cardiopulmonary bypass: changes in creatinine clearance.Ann Thorac Surg 72, no. 5 (November 2001): 1603–9. https://doi.org/10.1016/s0003-4975(01)03223-4.
Swaminathan M, East C, Phillips-Bute B, Newman MF, Reves JG, Smith PK, et al. Report of a substudy on warm versus cold cardiopulmonary bypass: changes in creatinine clearance. Ann Thorac Surg. 2001 Nov;72(5):1603–9.
Swaminathan, M., et al. “Report of a substudy on warm versus cold cardiopulmonary bypass: changes in creatinine clearance.Ann Thorac Surg, vol. 72, no. 5, Nov. 2001, pp. 1603–09. Pubmed, doi:10.1016/s0003-4975(01)03223-4.
Swaminathan M, East C, Phillips-Bute B, Newman MF, Reves JG, Smith PK, Stafford-Smith M. Report of a substudy on warm versus cold cardiopulmonary bypass: changes in creatinine clearance. Ann Thorac Surg. 2001 Nov;72(5):1603–1609.
Journal cover image

Published In

Ann Thorac Surg

DOI

ISSN

0003-4975

Publication Date

November 2001

Volume

72

Issue

5

Start / End Page

1603 / 1609

Location

Netherlands

Related Subject Headings

  • Temperature
  • Respiratory System
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Female
  • Creatinine
  • Cardiopulmonary Bypass
  • Aged