Transcranial Doppler blood flow velocity versus 133Xe clearance cerebral blood flow during mild hypothermic cardiopulmonary bypass.

Journal Article (Journal Article)

OBJECTIVE: Transcranial doppler (TCD) is used during cardiopulmonary bypass (CPB) to assess cerebral emboli and to estimate cerebral perfusion. We sought to compare TCD middle cerebral artery blood flow velocity (Vmca) to 133Xe clearance cerebral blood flow (CBF) measurements during mild hypothermic CPB thus determining its utility in cerebral perfusion assessment. METHODS: Thirty-four patients undergoing mild hypothermic CPB (35 degrees C) were studied and had comparisons of Vmca and 133Xe CBF at three time intervals, 10, 30 and 60 min after the institution of CPB. Linear regression analysis was performed on data from each of the 3 intervals as well as for pooled data from all 3 periods. RESULTS: The correlation coefficients for the 3 time periods were, r = 0.32 (p = 0.12), r = 0.32 (p = 0.11), r = 0.48 (p = (0.02), respectively. The pooled data correlation had a coefficient of 0.34 (p = 0.003). CONCLUSION: These findings suggest that TCD Vmca is a relatively poor correlate of CBF during mild hypothermic CPB.

Full Text

Duke Authors

Cited Authors

  • Grocott, HP; Amory, DW; Lowry, E; Croughwell, ND; Newman, MF

Published Date

  • January 1998

Published In

Volume / Issue

  • 14 / 1

Start / End Page

  • 35 - 39

PubMed ID

  • 9641854

International Standard Serial Number (ISSN)

  • 1387-1307

Digital Object Identifier (DOI)

  • 10.1023/a:1007493422230


  • eng

Conference Location

  • Netherlands