Skip to main content
Journal cover image

Neurological injury during cardiopulmonary bypass in the rat.

Publication ,  Journal Article
Grocott, HP; Mackensen, GB; Newman, MF; Warner, DS
Published in: Perfusion
January 2001

Cerebral injury is a well-known complication of cardiac surgery. Investigations of both injury mechanisms and neuroprotective strategies have partially been limited by the lack of an adequate preclinical model of small animal cardiopulmonary bypass (CPB). We sought to determine if neurological injury could be demonstrated in a recovery model of complete CPB in the rat. Rats (n = 5) underwent 45 min of normothermic CPB followed by 24 h of recovery. Compared to sham-operated rats (n = 5), the CPB group showed a worse neurological outcome score (median, 25-75th percentile) compared to controls (5, 4-7 vs 9, 8-9, p = 0.016). This rat model of CPB may allow for the study of CPB-associated neurological injury.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Perfusion

DOI

ISSN

0267-6591

Publication Date

January 2001

Volume

16

Issue

1

Start / End Page

75 / 81

Location

England

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Psychomotor Performance
  • Models, Animal
  • Male
  • Equipment Design
  • Echocardiography, Transesophageal
  • Cardiopulmonary Bypass
  • Brain Damage, Chronic
  • Body Temperature
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Grocott, H. P., Mackensen, G. B., Newman, M. F., & Warner, D. S. (2001). Neurological injury during cardiopulmonary bypass in the rat. Perfusion, 16(1), 75–81. https://doi.org/10.1177/026765910101600111
Grocott, H. P., G. B. Mackensen, M. F. Newman, and D. S. Warner. “Neurological injury during cardiopulmonary bypass in the rat.Perfusion 16, no. 1 (January 2001): 75–81. https://doi.org/10.1177/026765910101600111.
Grocott HP, Mackensen GB, Newman MF, Warner DS. Neurological injury during cardiopulmonary bypass in the rat. Perfusion. 2001 Jan;16(1):75–81.
Grocott, H. P., et al. “Neurological injury during cardiopulmonary bypass in the rat.Perfusion, vol. 16, no. 1, Jan. 2001, pp. 75–81. Pubmed, doi:10.1177/026765910101600111.
Grocott HP, Mackensen GB, Newman MF, Warner DS. Neurological injury during cardiopulmonary bypass in the rat. Perfusion. 2001 Jan;16(1):75–81.
Journal cover image

Published In

Perfusion

DOI

ISSN

0267-6591

Publication Date

January 2001

Volume

16

Issue

1

Start / End Page

75 / 81

Location

England

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Psychomotor Performance
  • Models, Animal
  • Male
  • Equipment Design
  • Echocardiography, Transesophageal
  • Cardiopulmonary Bypass
  • Brain Damage, Chronic
  • Body Temperature