Neurological injury during cardiopulmonary bypass in the rat.
Publication
, Journal Article
Grocott, HP; Mackensen, GB; Newman, MF; Warner, DS
Published in: Perfusion
January 2001
Cerebral injury is a well-known complication of cardiac surgery. Investigations of both injury mechanisms and neuroprotective strategies have partially been limited by the lack of an adequate preclinical model of small animal cardiopulmonary bypass (CPB). We sought to determine if neurological injury could be demonstrated in a recovery model of complete CPB in the rat. Rats (n = 5) underwent 45 min of normothermic CPB followed by 24 h of recovery. Compared to sham-operated rats (n = 5), the CPB group showed a worse neurological outcome score (median, 25-75th percentile) compared to controls (5, 4-7 vs 9, 8-9, p = 0.016). This rat model of CPB may allow for the study of CPB-associated neurological injury.
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Published In
Perfusion
DOI
ISSN
0267-6591
Publication Date
January 2001
Volume
16
Issue
1
Start / End Page
75 / 81
Location
England
Related Subject Headings
- Rats, Sprague-Dawley
- Rats
- Psychomotor Performance
- Models, Animal
- Male
- Equipment Design
- Echocardiography, Transesophageal
- Cardiopulmonary Bypass
- Brain Damage, Chronic
- Body Temperature
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Grocott, H. P., Mackensen, G. B., Newman, M. F., & Warner, D. S. (2001). Neurological injury during cardiopulmonary bypass in the rat. Perfusion, 16(1), 75–81. https://doi.org/10.1177/026765910101600111
Grocott, H. P., G. B. Mackensen, M. F. Newman, and D. S. Warner. “Neurological injury during cardiopulmonary bypass in the rat.” Perfusion 16, no. 1 (January 2001): 75–81. https://doi.org/10.1177/026765910101600111.
Grocott HP, Mackensen GB, Newman MF, Warner DS. Neurological injury during cardiopulmonary bypass in the rat. Perfusion. 2001 Jan;16(1):75–81.
Grocott, H. P., et al. “Neurological injury during cardiopulmonary bypass in the rat.” Perfusion, vol. 16, no. 1, Jan. 2001, pp. 75–81. Pubmed, doi:10.1177/026765910101600111.
Grocott HP, Mackensen GB, Newman MF, Warner DS. Neurological injury during cardiopulmonary bypass in the rat. Perfusion. 2001 Jan;16(1):75–81.
Published In
Perfusion
DOI
ISSN
0267-6591
Publication Date
January 2001
Volume
16
Issue
1
Start / End Page
75 / 81
Location
England
Related Subject Headings
- Rats, Sprague-Dawley
- Rats
- Psychomotor Performance
- Models, Animal
- Male
- Equipment Design
- Echocardiography, Transesophageal
- Cardiopulmonary Bypass
- Brain Damage, Chronic
- Body Temperature