Apolipoprotein E genotype and neurodevelopmental sequelae of infant cardiac surgery.


Journal Article

BACKGROUND: There has been increasing recognition of adverse neurodevelopmental sequelae in some children after repair of congenital heart defects. Even among children with the same cardiac defect, significant interindividual variation exists in developmental outcome. Polymorphisms of apolipoprotein E have been identified as a risk factor for worse neurologic recovery after central nervous system injury. METHODS: A single-institution prospective study of patients

Full Text

Duke Authors

Cited Authors

  • Gaynor, JW; Gerdes, M; Zackai, EH; Bernbaum, J; Wernovsky, G; Clancy, RR; Newman, MF; Saunders, AM; Heagerty, PJ; D'Agostino, JA; McDonald-McGinn, D; Nicolson, SC; Spray, TL; Jarvik, GP

Published Date

  • December 2003

Published In

Volume / Issue

  • 126 / 6

Start / End Page

  • 1736 - 1745

PubMed ID

  • 14688681

Pubmed Central ID

  • 14688681

Electronic International Standard Serial Number (EISSN)

  • 1097-685X

International Standard Serial Number (ISSN)

  • 0022-5223

Digital Object Identifier (DOI)

  • 10.1016/s0022


  • eng