Transcranial Doppler emboli count predicts rise in creatinine after coronary artery bypass graft surgery.

Journal Article (Journal Article)

OBJECTIVE: To examine the correlation between transcranial Doppler ultrasonography-detected emboli during coronary artery bypass graft surgery with cardiopulmonary bypass and renal dysfunction as determined by the postoperative change in creatinine. DESIGN: Retrospective review of data from the anesthesia and cardiothoracic surgery databases. SETTING: Tertiary care university hospital. PARTICIPANTS: Two hundred eighty-six patients undergoing coronary artery bypass graft surgery. INTERVENTIONS: Transcranial Doppler ultrasonography of the right middle cerebral artery was performed after induction of general anesthesia through completion of the operation. Doppler signals were recorded and emboli counts determined using an automated counting system. MEASUREMENTS AND MAIN RESULTS: Renal dysfunction was assessed as the change in creatinine from the preoperative value to the maximum postoperative value (Delta-Cr). There was a significant (p = 0.0003) univariate correlation between postoperative change in creatinine and total number of Doppler-detected emboli. The effect of total number of emboli remained significant (p = 0.0038) in the multivariable analysis after adjustment for covariables (age, sex, number of grafts, left ventricular ejection fraction, hypertension, history of congestive heart failure, diabetes, cardiopulmonary bypass time, preoperative creatinine, and maximum postoperative creatinine). CONCLUSIONS: Increased numbers of Doppler-detected emboli during coronary artery bypass graft surgery are associated with postoperative renal dysfunction.

Full Text

Duke Authors

Cited Authors

  • Sreeram, GM; Grocott, HP; White, WD; Newman, MF; Stafford-Smith, M

Published Date

  • October 2004

Published In

Volume / Issue

  • 18 / 5

Start / End Page

  • 548 - 551

PubMed ID

  • 15578463

International Standard Serial Number (ISSN)

  • 1053-0770

Digital Object Identifier (DOI)

  • 10.1053/j.jvca.2004.07.010


  • eng

Conference Location

  • United States