Skip to main content
Journal cover image

Positive selection driving diversification in plant secondary metabolism.

Publication ,  Journal Article
Benderoth, M; Textor, S; Windsor, AJ; Mitchell-Olds, T; Gershenzon, J; Kroymann, J
Published in: Proceedings of the National Academy of Sciences of the United States of America
June 2006

In Arabidopsis thaliana and related plants, glucosinolates are a major component in the blend of secondary metabolites and contribute to resistance against herbivorous insects. Methylthioalkylmalate synthases (MAM) encoded at the MAM gene cluster control an early step in the biosynthesis of glucosinolates and, therefore, are central to the diversification of glucosinolate metabolism. We sequenced bacterial artificial chromosomes containing the MAM cluster from several Arabidopsis relatives, conducted enzyme assays with heterologously expressed MAM genes, and analyzed MAM nucleotide variation patterns. Our results show that gene duplication, neofunctionalization, and positive selection provide the mechanism for biochemical adaptation in plant defense. These processes occur repeatedly in the history of the MAM gene family, indicating their fundamental importance for the evolution of plant metabolic diversity both within and among species.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

June 2006

Volume

103

Issue

24

Start / End Page

9118 / 9123

Related Subject Headings

  • Sequence Analysis, DNA
  • Sequence Alignment
  • Selection, Genetic
  • Phylogeny
  • Oxo-Acid-Lyases
  • Multigene Family
  • Molecular Sequence Data
  • Glucosinolates
  • Genetic Variation
  • Evolution, Molecular
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Benderoth, M., Textor, S., Windsor, A. J., Mitchell-Olds, T., Gershenzon, J., & Kroymann, J. (2006). Positive selection driving diversification in plant secondary metabolism. Proceedings of the National Academy of Sciences of the United States of America, 103(24), 9118–9123. https://doi.org/10.1073/pnas.0601738103
Benderoth, Markus, Susanne Textor, Aaron J. Windsor, Thomas Mitchell-Olds, Jonathan Gershenzon, and Juergen Kroymann. “Positive selection driving diversification in plant secondary metabolism.Proceedings of the National Academy of Sciences of the United States of America 103, no. 24 (June 2006): 9118–23. https://doi.org/10.1073/pnas.0601738103.
Benderoth M, Textor S, Windsor AJ, Mitchell-Olds T, Gershenzon J, Kroymann J. Positive selection driving diversification in plant secondary metabolism. Proceedings of the National Academy of Sciences of the United States of America. 2006 Jun;103(24):9118–23.
Benderoth, Markus, et al. “Positive selection driving diversification in plant secondary metabolism.Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 24, June 2006, pp. 9118–23. Epmc, doi:10.1073/pnas.0601738103.
Benderoth M, Textor S, Windsor AJ, Mitchell-Olds T, Gershenzon J, Kroymann J. Positive selection driving diversification in plant secondary metabolism. Proceedings of the National Academy of Sciences of the United States of America. 2006 Jun;103(24):9118–9123.
Journal cover image

Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

June 2006

Volume

103

Issue

24

Start / End Page

9118 / 9123

Related Subject Headings

  • Sequence Analysis, DNA
  • Sequence Alignment
  • Selection, Genetic
  • Phylogeny
  • Oxo-Acid-Lyases
  • Multigene Family
  • Molecular Sequence Data
  • Glucosinolates
  • Genetic Variation
  • Evolution, Molecular