Comparison of remifentanil with alfentanil or suxamethonium following propofol anaesthesia for tracheal intubation.

Journal Article (Clinical Trial;Journal Article)

Sixty ASA physical status I and II, premedicated patients were administered propofol 2 mg x kg-1 and remifentanil 2 microg x kg-1 (group R), alfentanil 50 microg x kg-1 (group A) or suxamethonium 1 mg x kg-1 (group S) as a rapid bolus. One minute after study drug administration, tracheal intubation was performed. Intubation conditions were then scored. Excellent or good conditions were observed in only 35% in group R compared with groups S and A (100% and 85%, respectively; p < 0.001). The haemodynamic response to tracheal intubation was blunted in groups R and A compared with group S (p < 0.001). The mean heart rate in groups R and A was significantly lower than group S (p < 0.001). We conclude that remifentanil 2 microg x kg-1 given as a rapid bolus will not produce intubating conditions as good as those obtained with alfentanil 50 microg x kg-1 or suxamethonium 1 mg x kg-1 if administered after propofol 2 mg x kg-1.

Full Text

Duke Authors

Cited Authors

  • Alexander, R; Booth, J; Olufolabi, AJ; El-Moalem, HE; Glass, PS

Published Date

  • November 1999

Published In

Volume / Issue

  • 54 / 11

Start / End Page

  • 1032 - 1036

PubMed ID

  • 10540090

International Standard Serial Number (ISSN)

  • 0003-2409

Digital Object Identifier (DOI)

  • 10.1046/j.1365-2044.1999.01070.x


  • eng

Conference Location

  • England