New paradigms in cardiovascular medicine: emerging technologies and practices: perioperative genomics.


Journal Article (Review)

Considerable progress has been made in understanding the pathophysiology of perioperative stress responses and their impact on the cardiovascular system; however, researchers are just beginning to unravel genetic and molecular determinants that predispose to increased risk for postoperative cardiovascular adverse events. A new field, coined perioperative genomics, aims to apply functional genomic approaches to uncover the biological reasons why similar patients can have dramatically different clinical outcomes after surgery. For the perioperative physician, such findings may soon translate into prospective risk assessment incorporating genomic profiling of markers important in inflammatory, thrombotic, vascular, and neurologic responses to perioperative stress, with implications ranging from individualized additional pre-operative testing and physiological optimization, to perioperative decision-making, choice of monitoring strategies, and critical care resource utilization. We review current knowledge regarding genomic technologies in perioperative cardiovascular disease characterization and outcome prediction, as well as discuss future trends/challenges for translating integrated "omic" information into daily clinical management of the surgical patient.

Full Text

Duke Authors

Cited Authors

  • Podgoreanu, MV; Schwinn, DA

Published Date

  • December 6, 2005

Published In

Volume / Issue

  • 46 / 11

Start / End Page

  • 1965 - 1977

PubMed ID

  • 16325027

Pubmed Central ID

  • 16325027

Electronic International Standard Serial Number (EISSN)

  • 1558-3597

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2005.08.040


  • eng

Conference Location

  • United States