Calmodulin and CaMKII as molecular switches for cardiac ion channels.
Journal Article (Journal Article;Review)
Because changes in intracellular Ca(2+) concentration are the final signals of electrical activity in excitable cells, many mechanisms have evolved to regulate Ca(2+) influx. Among the most important are those pathways that directly regulate the ion channels responsible for regulating and generating the Ca(2+) influx signal. Recent work has demonstrated that the Ca(2+) binding protein calmodulin (CaM) and the Ca(2+)/CaM-sensitive kinase CaMKII are important modulators of cardiac ion channels. Thus, Ca(2+) participates in feedback modulation to control electrical activity. This review highlights various mechanisms by which CaM and CaMKII regulate cardiovascular ion channel activity and presents a novel model for CaMKII regulation of Ca(V)1.2 Ca(2+) channel function.
Full Text
Duke Authors
Cited Authors
- Pitt, GS
Published Date
- March 1, 2007
Published In
Volume / Issue
- 73 / 4
Start / End Page
- 641 - 647
PubMed ID
- 17137569
International Standard Serial Number (ISSN)
- 0008-6363
Digital Object Identifier (DOI)
- 10.1016/j.cardiores.2006.10.019
Language
- eng
Conference Location
- England