Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family.

Journal Article

In this study, a protein that interacts with sequences encoded by the first exon of the protein kinase Bcr was cloned. The Bcr-associated protein 1 (Bap-1) is a member of the 14-3-3 family of proteins. Bap-1 interacts with full-length c-Bcr and with the chimeric Bcr-Abl tyrosine kinase of Philadelphia chromosome (Ph1)-positive human leukemias. Bap-1 is a substrate for the Bcr serine-threonine kinase and is also phosphorylated on tyrosine by Bcr-Abl but not by c-Abl. Bap-1 may function in the regulation of c-Bcr and may contribute to the transforming activity of Bcr-Abl in vivo. 14-3-3 proteins are essential for cell proliferation and have a role in determining the timing of mitosis in yeast. Through direct binding to sequences present in Bcr and in other proteins implicated in signaling, the mammalian 14-3-3 proteins may link specific signaling protein components to mitogenic and cell-cycle control pathways.

Full Text

Duke Authors

Cited Authors

  • Reuther, GW; Fu, H; Cripe, LD; Collier, RJ; Pendergast, AM

Published Date

  • October 7, 1994

Published In

Volume / Issue

  • 266 / 5182

Start / End Page

  • 129 - 133

PubMed ID

  • 7939633

International Standard Serial Number (ISSN)

  • 0036-8075

Language

  • eng

Conference Location

  • United States