Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.

Published

Journal Article

Oncogenic activation of the proto-oncogene c-abl in human leukemias occurs as a result of the addition of exons from the gene bcr and truncation of the first abl exon. Analysis of tyrosine kinase activity and quantitative measurement of transformation potency in a single-step assay indicate that variation in bcr exon contribution results in a functional difference between p210bcr-abl and p185bcr-abl proteins. Thus, foreign upstream sequences are important in the deregulation of the kinase activity of the abl product, and the extent of deregulation correlates with the pathological effects of the bcr-abl proteins.

Full Text

Duke Authors

Cited Authors

  • Lugo, TG; Pendergast, AM; Muller, AJ; Witte, ON

Published Date

  • March 1990

Published In

Volume / Issue

  • 247 / 4946

Start / End Page

  • 1079 - 1082

PubMed ID

  • 2408149

Pubmed Central ID

  • 2408149

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.2408149

Language

  • eng