Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.
Journal Article (Journal Article)
Oncogenic activation of the proto-oncogene c-abl in human leukemias occurs as a result of the addition of exons from the gene bcr and truncation of the first abl exon. Analysis of tyrosine kinase activity and quantitative measurement of transformation potency in a single-step assay indicate that variation in bcr exon contribution results in a functional difference between p210bcr-abl and p185bcr-abl proteins. Thus, foreign upstream sequences are important in the deregulation of the kinase activity of the abl product, and the extent of deregulation correlates with the pathological effects of the bcr-abl proteins.
Full Text
Duke Authors
Cited Authors
- Lugo, TG; Pendergast, AM; Muller, AJ; Witte, ON
Published Date
- March 2, 1990
Published In
Volume / Issue
- 247 / 4946
Start / End Page
- 1079 - 1082
PubMed ID
- 2408149
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.2408149
Language
- eng
Conference Location
- United States