Bcr-Abl variants: biological and clinical aspects.
Publication
, Journal Article
Advani, AS; Pendergast, AM
Published in: Leuk Res
August 2002
Bcr-Abl is an oncogene that arises from fusion of the Bcr gene with the c-Abl proto-oncogene. Three different Bcr-Abl variants can be formed, depending on the amount of Bcr gene included: p185, p210, and p230. The three variants are associated with distinct types of human leukemias. Examination of the signaling pathways differentially regulated by the Bcr-Abl proteins will help us gain better insight into Bcr-Abl mediated leukemogenesis.
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Published In
Leuk Res
DOI
ISSN
0145-2126
Publication Date
August 2002
Volume
26
Issue
8
Start / End Page
713 / 720
Location
England
Related Subject Headings
- Proto-Oncogene Mas
- Philadelphia Chromosome
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Immunology
- Humans
- Genetic Variation
- Genes, abl
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Advani, A. S., & Pendergast, A. M. (2002). Bcr-Abl variants: biological and clinical aspects. Leuk Res, 26(8), 713–720. https://doi.org/10.1016/s0145-2126(01)00197-7
Advani, Anjali S., and Ann Marie Pendergast. “Bcr-Abl variants: biological and clinical aspects.” Leuk Res 26, no. 8 (August 2002): 713–20. https://doi.org/10.1016/s0145-2126(01)00197-7.
Advani AS, Pendergast AM. Bcr-Abl variants: biological and clinical aspects. Leuk Res. 2002 Aug;26(8):713–20.
Advani, Anjali S., and Ann Marie Pendergast. “Bcr-Abl variants: biological and clinical aspects.” Leuk Res, vol. 26, no. 8, Aug. 2002, pp. 713–20. Pubmed, doi:10.1016/s0145-2126(01)00197-7.
Advani AS, Pendergast AM. Bcr-Abl variants: biological and clinical aspects. Leuk Res. 2002 Aug;26(8):713–720.
Published In
Leuk Res
DOI
ISSN
0145-2126
Publication Date
August 2002
Volume
26
Issue
8
Start / End Page
713 / 720
Location
England
Related Subject Headings
- Proto-Oncogene Mas
- Philadelphia Chromosome
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Immunology
- Humans
- Genetic Variation
- Genes, abl
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences