Bcr-Abl variants: biological and clinical aspects.

Journal Article (Journal Article;Review)

Bcr-Abl is an oncogene that arises from fusion of the Bcr gene with the c-Abl proto-oncogene. Three different Bcr-Abl variants can be formed, depending on the amount of Bcr gene included: p185, p210, and p230. The three variants are associated with distinct types of human leukemias. Examination of the signaling pathways differentially regulated by the Bcr-Abl proteins will help us gain better insight into Bcr-Abl mediated leukemogenesis.

Full Text

Duke Authors

Cited Authors

  • Advani, AS; Pendergast, AM

Published Date

  • August 2002

Published In

Volume / Issue

  • 26 / 8

Start / End Page

  • 713 - 720

PubMed ID

  • 12191565

International Standard Serial Number (ISSN)

  • 0145-2126

Digital Object Identifier (DOI)

  • 10.1016/s0145-2126(01)00197-7


  • eng

Conference Location

  • England