Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway.
Oncogenic forms of the Abl and Src tyrosine kinases trigger the destruction of the Abi proteins, a family of Abl-interacting proteins that antagonize the oncogenic potential of Abl after overexpression in fibroblasts. The destruction of the Abi proteins requires tyrosine kinase activity and is dependent on the ubiquitin-proteasome pathway. We show that degradation of the Abi proteins occurs through a Ras-independent pathway. Significantly, expression of the Abi proteins is lost in cell lines and bone marrow cells isolated from patients with aggressive Bcr-Abl-positive leukemias. These findings suggest that loss of Abi proteins may be a component in the progression of Bcr-Abl-positive leukemias and identify a novel pathway linking activated nonreceptor protein tyrosine kinases to the destruction of specific target proteins through the ubiquitin-proteasome pathway.
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- ras Proteins
- Ubiquitins
- Tumor Cells, Cultured
- Proto-Oncogene Proteins pp60(c-src)
- Proto-Oncogene Proteins c-abl
- Protein Processing, Post-Translational
- Proteasome Endopeptidase Complex
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
- Neoplasm Proteins
- Multienzyme Complexes
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- ras Proteins
- Ubiquitins
- Tumor Cells, Cultured
- Proto-Oncogene Proteins pp60(c-src)
- Proto-Oncogene Proteins c-abl
- Protein Processing, Post-Translational
- Proteasome Endopeptidase Complex
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
- Neoplasm Proteins
- Multienzyme Complexes