Solitary fibrous tumor of the meninges occurring after irradiation of a mixed germ cell tumor of the pineal gland.

Published

Journal Article

Twenty-nine months after surgery, irradiation, and systemic chemotherapy for a pineal mixed germ cell tumor, an 11-year-old Caucasian male developed a 3 cm dural based nodule in the occipital lobe that proved to be a solitary fibrous tumor by immunohistochemical and ultrastructural examination. Differential diagnosis included fibrous meningioma, neurofibroma, Schwannoma, cranial fasciitis of infancy, and solitary fibrous tumor. A Masson trichrome stain revealed a prominent collagenous stroma and reticulin staining exhibited strong pericellular positivity. Immunohistochemical staining demonstrated diffuse vimentin and focal CD34 positivity of tumor cells. Ultrastructural examination revealed fibroblastic differentiation. These features are consistent with solitary fibrous tumor. Although we favor a radiation-induced origin for the neoplasm, alternative explanations for the tumor's origin include cerebrospinal fluid spread from the original germ cell tumor or a de novo neoplasm.

Full Text

Duke Authors

Cited Authors

  • Slavik, T; Bentley, RC; Gray, L; Fuchs, HE; McLendon, RE

Published Date

  • January 1998

Published In

Volume / Issue

  • 17 / 1

Start / End Page

  • 55 - 60

PubMed ID

  • 9496542

Pubmed Central ID

  • 9496542

International Standard Serial Number (ISSN)

  • 0722-5091

Language

  • eng

Conference Location

  • Germany