Morphologic and molecular genetic aspects of oligodendroglial neoplasms.

Journal Article (Review)

Morphologic criteria for diagnosing oligodendrogliomas and for classifying them as well-differentiated (World Health Organization grade II) and anaplastic (World Health Organization grade III) are well recognized. Nevertheless, applying these guidelines to specific cases often reveals discrepancies among different observers. In addition, whether a given tumor also contains an astrocytic component may be debatable. Loss of heterozygosity studies have demonstrated that oligodendroglial neoplasms have a high incidence of loss of the 1p and 19q chromosomal arms. Although loss of heterozygosity for portions of 19q are sometimes seen in astrocytic neoplasms, these tumors seldom show complete loss of 19q accompanied by loss of 1p. Loss of 9p or homozygous deletion of the CDKN2 gene or both are associated with anaplastic oligodendrogliomas, whereas loss of 17p or TP53 gene mutations or both are frequent in astrocytomas, but rare in oligodendrogliomas. These observations suggest that molecular genetic parameters could provide an objective, reproducible framework for classifying oligodendroglial neoplasms.

Full Text

Duke Authors

Cited Authors

  • Bigner, SH; Rasheed, BK; Wiltshire, R; McLendon, RE

Published Date

  • January 1999

Published In

Volume / Issue

  • 1 / 1

Start / End Page

  • 52 - 60

PubMed ID

  • 11550302

International Standard Serial Number (ISSN)

  • 1522-8517

Language

  • eng

Conference Location

  • England