Biphasic malignant meningioma: a comparative genomic hybridization study.

Published

Journal Article

To ascertain if a carcinoma-like component within a fibroblastic meningioma represented a metastatic carcinoma to a meningioma or malignant progression, we employed traditional immunohistochemical methods as well as comparative genomic hybridization (CGH) which compares chromosomal alterations. Vimentin and epithelial membrane antigen were strongly immunoreactive in both the fibroblastic and carcinoma-like components. The CGH profile in both components had similar chromosomal alterations, including losses of 1p, 14, 16p13-->p10 and 22. However, the CGH profiles from the fibroblastic component showed losses of 4p, 10q23-->q24 and 18, along with gains of 1q, 6q25-->qter and 13q32-->qter. The profile of the carcinoma-like component showed losses of chromosome 4, in addition to gains of 3p12-->q13.11, 5q14.3-->q23.2, 6pter-->p23, and 13q14.2-->qter. CGH analysis of a biphasic malignant meningioma confirmed that the disparate histologic components were genetically related and likely derivative from a common precursor, demonstrating genetic instability and clonal expansion. Furthermore, CGH showed that the histologically appearing low-grade fibroblastic component had not solely the characteristic alterations of a benign meningioma but had already progressed to an atypical meningioma.

Full Text

Duke Authors

Cited Authors

  • Heimberger, AB; Wiltshire, RN; Bronec, R; McLendon, RE; Cummings, TJ

Published Date

  • November 2002

Published In

Volume / Issue

  • 21 / 6

Start / End Page

  • 258 - 264

PubMed ID

  • 12489674

Pubmed Central ID

  • 12489674

International Standard Serial Number (ISSN)

  • 0722-5091

Language

  • eng

Conference Location

  • Germany