Clinicopathologic correlations in the oligodendroglioma.

Journal Article (Journal Article)

To determine the prognostic significance of histologic variables in oligodendroglial neoplasms, the presence and degree of 15 such variables were correlated with postoperative survival rates in 71 patients. By univariate analysis, prognostically significant factors, in order of decreasing importance, were mitoses (log), necrosis, nuclear cytologic atypia, vascular hypertrophy, and vascular proliferation. When studied by stepwise regression, necrosis and the number of mitoses contained all of the prognostically useful information. When each of the five variables significant by univariate analysis was tested in the Cox model by adding a variable to the model containing the other four, necrosis was found to be the only independently significant variable. There were significant positive pairwise correlations between each of the five significant histologic variables except for cytologic atypia with necrosis. The only histologic variable with a significant association with older age was the number of mitoses. These results suggest that necrosis and, to a lesser extent, the mitotic count are features that, in the appropriate setting, can be used to identify the "anaplastic" oligodendroglioma.

Full Text

Duke Authors

Cited Authors

  • Burger, PC; Rawlings, CE; Cox, EB; McLendon, RE; Schold, SC; Bullard, DE

Published Date

  • April 1, 1987

Published In

Volume / Issue

  • 59 / 7

Start / End Page

  • 1345 - 1352

PubMed ID

  • 3545437

International Standard Serial Number (ISSN)

  • 0008-543X

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19870401)59:7<1345::aid-cncr2820590719>;2-a


  • eng

Conference Location

  • United States