Castleman's disease confined to the leptomeninges.

Journal Article (Journal Article;Review)

We report a rare case of the plasma cell variant of Castleman's disease confined to the leptomeninges in a 42-year-old female. Flow cytometry demonstrated a minor monoclonal kappa light chain population, and conventional Southern blotting confirmed clonal rearrangement of the J(H) immunoglobulin heavy-chain gene. Polymerase chain reaction for Epstein-Barr virus and Kaposi's sarcoma-associated herpes virus was negative. The patient is disease-free five years after surgical resection. To our knowledge, clonal gene rearrangement has not been previously reported in the plasma cell variant of localized intracranial Castleman's disease.

Full Text

Duke Authors

Cited Authors

  • Cummings, TJ; Gong, JZ; Friedman, AH; McLendon, RE

Published Date

  • July 2000

Published In

Volume / Issue

  • 30 / 3

Start / End Page

  • 278 - 282

PubMed ID

  • 10945568

International Standard Serial Number (ISSN)

  • 0091-7370


  • eng

Conference Location

  • United States