Gliomatosis cerebri: cytologic and autopsy findings in a case involving the entire neuraxis.
Published
Journal Article
We describe the case of a 7-year-old girl who was clinically diagnosed as having a pontine glioma based on magnetic resonance imaging studies. Neoplastic cells were identified upon cytologic examination of cerebrospinal fluid. Autopsy studies revealed an anaplastic astrocytoma (WHO grade III) diffusely infiltrating the cerebral hemispheres, brain stem, cerebellum, leptomeninges, and spinal cord to the level of the conus medullaris. The Ki-67 labeling index focally approached 30%. Although many of the neoplastic cells displayed elongated twisted nuclei reminiscent of microglia, these cells stained intensely for glial fibrillary acidic protein, supporting an astrocytic origin. Unusual features of this case of gliomatosis cerebri include involvement of the entire central neuraxis, correlation with pre-mortem lumbar puncture cytology, and a markedly elevated Ki-67 labeling index.
Full Text
Duke Authors
Cited Authors
- Cummings, TJ; Hulette, CM; Longee, DC; Bottom, KS; McLendon, RE; Chu, CT
Published Date
- July 1999
Published In
Volume / Issue
- 18 / 4
Start / End Page
- 190 - 197
PubMed ID
- 10442461
Pubmed Central ID
- 10442461
International Standard Serial Number (ISSN)
- 0722-5091
Language
- eng
Conference Location
- Germany