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Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25.

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Rasheed, BK; McLendon, RE; Friedman, HS; Friedman, AH; Fuchs, HE; Bigner, DD; Bigner, SH
Published in: Oncogene
June 1, 1995

The high incidence of loss of chromosome 10 alleles in glioblastoma multiforme suggests the presence on this chromosome of a tumor suppressor gene that is important in glioma tumorigenesis and progression. Our initial deletion mapping studies using restriction fragment length polymorphism markers indicated a common deletion region in 10q24-qter. In an attempt to localize the deleted region further, we screened a panel of 117 gliomas for loss of heterozygosity for chromosome 10 loci using 10 microsatellite markers. Seventeen tumors showed partial loss of a copy of chromosome 10 and were further analysed using 28 additional microsatellite markers. Of these, 10 had terminal deletion in the q arm, three had deletions in both p and q arms, two contained interstitial deletion in 10q and two carried deletions in 10p. In the 15 tumors with deletions in 10q, the minimal overlapping deletion region was in distal 10q between markers D10S587 and D10S216. Loci D10S587 and D10S216 are approximately mapped to a 5 cM region in 10q25.1.

Duke Scholars

Published In

Oncogene

ISSN

0950-9232

Publication Date

June 1, 1995

Volume

10

Issue

11

Start / End Page

2243 / 2246

Location

England

Related Subject Headings

  • Tumor Cells, Cultured
  • Oncology & Carcinogenesis
  • Humans
  • Heterozygote
  • Glioma
  • Chromosomes, Human, Pair 10
  • Chromosome Deletion
  • Brain Neoplasms
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
 

Citation

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Rasheed, B. K., McLendon, R. E., Friedman, H. S., Friedman, A. H., Fuchs, H. E., Bigner, D. D., & Bigner, S. H. (1995). Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25. Oncogene. England.
Rasheed, B. K., R. E. McLendon, H. S. Friedman, A. H. Friedman, H. E. Fuchs, D. D. Bigner, and S. H. Bigner. “Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25.Oncogene, June 1, 1995.
Rasheed BK, McLendon RE, Friedman HS, Friedman AH, Fuchs HE, Bigner DD, et al. Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25. Vol. 10, Oncogene. 1995. p. 2243–6.
Rasheed, B. K., et al. “Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25.Oncogene, vol. 10, no. 11, 1 June 1995, pp. 2243–46.
Rasheed BK, McLendon RE, Friedman HS, Friedman AH, Fuchs HE, Bigner DD, Bigner SH. Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25. Oncogene. 1995. p. 2243–2246.

Published In

Oncogene

ISSN

0950-9232

Publication Date

June 1, 1995

Volume

10

Issue

11

Start / End Page

2243 / 2246

Location

England

Related Subject Headings

  • Tumor Cells, Cultured
  • Oncology & Carcinogenesis
  • Humans
  • Heterozygote
  • Glioma
  • Chromosomes, Human, Pair 10
  • Chromosome Deletion
  • Brain Neoplasms
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology