Contemporary management of patients with left ventricular systolic dysfunction. Results from the Study of Patients Intolerant of Converting Enzyme Inhibitors (SPICE) Registry.

Journal Article (Journal Article)

AIMS: The reported prevalence of angiotensin-converting enzyme (ACE) inhibitor use in patients with heart failure varies considerably. Recent reports suggest that many patients who could benefit from such therapy are not receiving ACE inhibitors. The Study of Patients Intolerant of Converting Enzyme Inhibitors (SPICE) Registry was established to understand better the demographics, characteristics, and contemporary use of ACE inhibitors in an international registry. METHODS AND RESULTS: Between August 1996 and April 1997, each of 105 study centres from eight countries in North America and Europe was invited to review retrospectively the medical records of 100 consecutive patients with left ventricular ejection fractions

Full Text

Duke Authors

Cited Authors

  • Bart, BA; Ertl, G; Held, P; Kuch, J; Maggioni, AP; McMurray, J; Michelson, EL; Rouleau, JL; Warner Stevenson, L; Swedberg, K; Young, JB; Yusuf, S; Sellers, MA; Granger, CB; Califf, RM; Pfeffer, MA

Published Date

  • August 1999

Published In

Volume / Issue

  • 20 / 16

Start / End Page

  • 1182 - 1190

PubMed ID

  • 10448027

International Standard Serial Number (ISSN)

  • 0195-668X

Digital Object Identifier (DOI)

  • 10.1053/euhj.1998.1481


  • eng

Conference Location

  • England