Incidence and impact on outcome of streptokinase allergy in the GUSTO-I trial. Global Utilization of Streptokinase and t-PA in Occluded Coronary Arteries.

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

We evaluated allergic reactions in 20,201 patients randomized to the streptokinase arms of The Global Utilization of Streptokinase and t-PA (Tissue Plasminogen Activator) in Occluded Coronary Arteries (GUSTO-I) trial, and tested the hypothesis that patients with streptokinase allergy would exhibit higher mortality. After adjusting for baseline variables and time of death, we found comparable coronary patency, left ventricular function, mortality, and bleeding complications between patients with versus those without streptokinase allergy.

Full Text

Duke Authors

Cited Authors

  • Tsang, TS; Califf, RM; Stebbins, AL; Lee, KL; Cho, S; Ross, AM; Armstrong, PW

Published Date

  • May 1, 1997

Published In

Volume / Issue

  • 79 / 9

Start / End Page

  • 1232 - 1235

PubMed ID

  • 9164891

International Standard Serial Number (ISSN)

  • 0002-9149

Digital Object Identifier (DOI)

  • 10.1016/s0002-9149(97)00087-8


  • eng

Conference Location

  • United States