Value of serial troponin T measures for early and late risk stratification in patients with acute coronary syndromes. The GUSTO-IIa Investigators.

Journal Article (Journal Article)

BACKGROUND: The baseline cardiac troponin T (cTnT) level strongly predicts short-term mortality in acute coronary syndromes, but the added value of later measures to predict short- and long-term outcome and in the context of baseline clinical characteristics is unclear. METHODS AND RESULTS: Relations between baseline, peak, and 8- and 16-hour (late) cTnT results and outcomes were assessed in 734 patients in a GUSTO-IIa substudy. Proportional-hazards models assessed the prognostic information gained from late cTnT when added to a mortality model containing the baseline cTnT result and clinical factors. At baseline, 260 patients were cTnT-positive (>0.1 ng/mL), 323 became positive later, and 151 remained negative (

Full Text

Duke Authors

Cited Authors

  • Newby, LK; Christenson, RH; Ohman, EM; Armstrong, PW; Thompson, TD; Lee, KL; Hamm, CW; Katus, HA; Cianciolo, C; Granger, CB; Topol, EJ; Califf, RM

Published Date

  • November 3, 1998

Published In

Volume / Issue

  • 98 / 18

Start / End Page

  • 1853 - 1859

PubMed ID

  • 9799204

Pubmed Central ID

  • 9799204

International Standard Serial Number (ISSN)

  • 0009-7322

Digital Object Identifier (DOI)

  • 10.1161/01.cir.98.18.1853


  • eng

Conference Location

  • United States