Redefining medical treatment in the management of unstable angina.


Journal Article (Review)

In 1994, the Agency for Health Care Policy and Research sponsored the development of guidelines for diagnosing and managing patients with unstable angina. Since their publication, several important developments have occurred. The prognostic value of biochemical assays for cardiac-specific troponins T and I have been shown in many studies. The possible role for C-reactive protein in determining prognosis deserves further investigation. Substantial clinical benefits have been obtained with intravenous inhibitors of the platelet glycoprotein (GP) IIb-IIIa receptor (abciximab, eptifibatide, tirofiban) and with one of the low-molecular-weight heparins (enoxaparin). The therapeutic potential of other low-molecular-weight heparins, direct thrombin inhibitors, and oral GP IIb-IIIa inhibitors remains to be clarified. On the basis of this evidence, consideration should be given to measuring serum levels of a cardiac troponin (either T or I) and using intravenous GP IIb-IIIa inhibitors and low-molecular-weight heparin in the standard management of patients with unstable angina.

Full Text

Duke Authors

Cited Authors

  • Braunwald, E; Califf, RM; Cannon, CP; Fox, KA; Fuster, V; Gibler, WB; Harrington, RA; King, SB; Kleiman, NS; Theroux, P; Topol, EJ; Van de Werf, F; White, HD; Willerson, JT

Published Date

  • January 2000

Published In

Volume / Issue

  • 108 / 1

Start / End Page

  • 41 - 53

PubMed ID

  • 11059440

Pubmed Central ID

  • 11059440

International Standard Serial Number (ISSN)

  • 0002-9343

Digital Object Identifier (DOI)

  • 10.1016/s0002-9343(99)00416-7


  • eng

Conference Location

  • United States