Correlation between baseline plasminogen activator inhibitor levels and clinical outcome during therapy with tissue plasminogen activator for acute myocardial infarction.


Journal Article

Baseline plasminogen activator inhibitor (PAI) levels were examined for their influence on the responses to thrombolysis with recombinant tissue plasminogen activator (rt-PA) administered for acute myocardial infarction during the Thrombolysis and Myocardial Infarction (TAMI)-I study. Baseline PAI activity was 19 +/- 21 IU/ml (normal less than 5 IU/ml) and baseline PAI-1 antigen 54 +/- 53 ng/ml (normal 27 +/- 16 ng/ml), confirming previous findings of elevated PAI levels during acute myocardial infarction. Among clinical outcomes, lower PAI-1 antigen levels correlated weakly with greater patency at the 90 min angiogram. Thus, high baseline plasma PAI-1 levels may be detrimental to reperfusion with t-PA. There was no correlation with other major in-hospital clinical outcomes including reocclusion at the 7-10 day angiogram, survival to discharge, or bleeding. During the follow up period of 2.0 +/- 0.4 years, no relationship between baseline PAI levels and post-discharge reinfarction was observed.

Full Text

Duke Authors

Cited Authors

  • Sane, DC; Stump, DC; Topol, EJ; Sigmon, KN; Kereiakes, DJ; George, BS; Mantell, SJ; Macy, E; Collen, D; Califf, RM

Published Date

  • March 4, 1991

Published In

Volume / Issue

  • 65 / 3

Start / End Page

  • 275 - 279

PubMed ID

  • 1904653

Pubmed Central ID

  • 1904653

International Standard Serial Number (ISSN)

  • 0340-6245


  • eng

Conference Location

  • Germany