The physician wishing to estimate the risk of death for a patient experiencing acute myocardial infarction can rapidly use parameters available on first seeing the patient to estimate the expected mortality and can update this risk during the early phase of the event. From the initial evaluation, factors that exclude patients from reperfusion therapy constitute a substantially elevated risk. Older age, haemodynamic distress, and markers of ongoing ischaemia provide a large amount of prognostic information from the initial exam. Careful surveillance for additional complications allows continuous risk assessment during the early course.