A meta-analysis of randomized trials of calcium antagonists to reduce restenosis after coronary angioplasty.
Journal Article (Clinical Trial;Journal Article)
The usefulness of calcium antagonists to reduce restenosis after coronary angioplasty remains uncertain despite 5 randomized trials involving 919 patients. Review and meta-analysis of these trials are performed to provide insight into whether calcium antagonists reduce angiographic restenosis. In aggregate, these trials suggest that patients treated with calcium antagonists had approximately a 30% reduction in the odds of angiographic restenosis (odds ratio = 0.68; 95% confidence interval of 0.49 to 0.94, p = 0.03) compared with control patients. Given the relatively low toxicity and cost of these agents, this reduction in angiographic restenosis may translate into a meaningful clinical benefit. A large, randomized clinical trial should be performed to confirm these findings before widespread adoption of this treatment strategy.
Full Text
Duke Authors
Cited Authors
- Hillegass, WB; Ohman, EM; Leimberger, JD; Califf, RM
Published Date
- May 1, 1994
Published In
Volume / Issue
- 73 / 12
Start / End Page
- 835 - 839
PubMed ID
- 8184803
International Standard Serial Number (ISSN)
- 0002-9149
Digital Object Identifier (DOI)
- 10.1016/0002-9149(94)90805-2
Language
- eng
Conference Location
- United States