A meta-analysis of randomized trials of calcium antagonists to reduce restenosis after coronary angioplasty.

Journal Article (Clinical Trial;Journal Article)

The usefulness of calcium antagonists to reduce restenosis after coronary angioplasty remains uncertain despite 5 randomized trials involving 919 patients. Review and meta-analysis of these trials are performed to provide insight into whether calcium antagonists reduce angiographic restenosis. In aggregate, these trials suggest that patients treated with calcium antagonists had approximately a 30% reduction in the odds of angiographic restenosis (odds ratio = 0.68; 95% confidence interval of 0.49 to 0.94, p = 0.03) compared with control patients. Given the relatively low toxicity and cost of these agents, this reduction in angiographic restenosis may translate into a meaningful clinical benefit. A large, randomized clinical trial should be performed to confirm these findings before widespread adoption of this treatment strategy.

Full Text

Duke Authors

Cited Authors

  • Hillegass, WB; Ohman, EM; Leimberger, JD; Califf, RM

Published Date

  • May 1, 1994

Published In

Volume / Issue

  • 73 / 12

Start / End Page

  • 835 - 839

PubMed ID

  • 8184803

International Standard Serial Number (ISSN)

  • 0002-9149

Digital Object Identifier (DOI)

  • 10.1016/0002-9149(94)90805-2


  • eng

Conference Location

  • United States