Risk factors for intracranial hemorrhage and nonhemorrhagic stroke after fibrinolytic therapy (from the GUSTO-i trial).


Journal Article

Of 592 patients in the Global Utilization of Streptokinase and tPA for Occluded Arteries-I trial who had a stroke during initial hospitalization, the risk for intracranial hemorrhage was significantly greater in those with recent facial or head trauma (odds ratio 13.0, 95% confidence interval 3.4 to 85.5); dementia was additionally associated with an increased risk for intracranial hemorrhage (odds ratio 3.4, 95% confidence interval 1.2 to 10.2). Because facial or head trauma may greatly influence treatment decisions, this risk factor should be incorporated into models designed to estimate the risks and benefits of fibrinolytic therapy.

Full Text

Duke Authors

Cited Authors

  • Kandzari, DE; Granger, CB; Simoons, ML; White, HD; Simes, J; Mahaffey, KW; Gore, J; Weaver, WD; Longstreth, WT; Stebbins, A; Lee, KL; Califf, RM; Topol, EJ; Global Utilization of Streptokinase and tPA for Occluded Arteries-I Investigators,

Published Date

  • February 15, 2004

Published In

Volume / Issue

  • 93 / 4

Start / End Page

  • 458 - 461

PubMed ID

  • 14969623

Pubmed Central ID

  • 14969623

International Standard Serial Number (ISSN)

  • 0002-9149

Digital Object Identifier (DOI)

  • 10.1016/j.amjcard.2003.10.043


  • eng

Conference Location

  • United States