Initial sequencing and comparative analysis of the mouse genome.

Published

Journal Article

The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.

Full Text

Duke Authors

Cited Authors

  • Mouse Genome Sequencing Consortium, ; Waterston, RH; Lindblad-Toh, K; Birney, E; Rogers, J; Abril, JF; Agarwal, P; Agarwala, R; Ainscough, R; Alexandersson, M; An, P; Antonarakis, SE; Attwood, J; Baertsch, R; Bailey, J; Barlow, K; Beck, S; Berry, E; Birren, B; Bloom, T; Bork, P; Botcherby, M; Bray, N; Brent, MR; Brown, DG; Brown, SD; Bult, C; Burton, J; Butler, J; Campbell, RD; Carninci, P; Cawley, S; Chiaromonte, F; Chinwalla, AT; Church, DM; Clamp, M; Clee, C; Collins, FS; Cook, LL; Copley, RR; Coulson, A; Couronne, O; Cuff, J; Curwen, V; Cutts, T; Daly, M; David, R; Davies, J; Delehaunty, KD; Deri, J; Dermitzakis, ET; Dewey, C; Dickens, NJ; Diekhans, M; Dodge, S; Dubchak, I; Dunn, DM; Eddy, SR; Elnitski, L; Emes, RD; Eswara, P; Eyras, E; Felsenfeld, A; Fewell, GA; Flicek, P; Foley, K; Frankel, WN; Fulton, LA; Fulton, RS; Furey, TS; Gage, D; Gibbs, RA; Glusman, G; Gnerre, S; Goldman, N; Goodstadt, L; Grafham, D; Graves, TA; Green, ED; Gregory, S; Guigó, R; Guyer, M; Hardison, RC; Haussler, D; Hayashizaki, Y; Hillier, LW; Hinrichs, A; Hlavina, W; Holzer, T; Hsu, F; Hua, A; Hubbard, T; Hunt, A; Jackson, I; Jaffe, DB; Johnson, LS; Jones, M; Jones, TA; Joy, A; Kamal, M; Karlsson, EK; Karolchik, D; Kasprzyk, A; Kawai, J; Keibler, E; Kells, C; Kent, WJ; Kirby, A; Kolbe, DL; Korf, I; Kucherlapati, RS; Kulbokas, EJ; Kulp, D; Landers, T; Leger, JP; Leonard, S; Letunic, I; Levine, R; Li, J; Li, M; Lloyd, C; Lucas, S; Ma, B; Maglott, DR; Mardis, ER; Matthews, L; Mauceli, E; Mayer, JH; McCarthy, M; McCombie, WR; McLaren, S; McLay, K; McPherson, JD; Meldrim, J; Meredith, B; Mesirov, JP; Miller, W; Miner, TL; Mongin, E; Montgomery, KT; Morgan, M; Mott, R; Mullikin, JC; Muzny, DM; Nash, WE; Nelson, JO; Nhan, MN; Nicol, R; Ning, Z; Nusbaum, C; O'Connor, MJ; Okazaki, Y; Oliver, K; Overton-Larty, E; Pachter, L; Parra, G; Pepin, KH; Peterson, J; Pevzner, P; Plumb, R; Pohl, CS; Poliakov, A; Ponce, TC; Ponting, CP; Potter, S; Quail, M; Reymond, A; Roe, BA; Roskin, KM; Rubin, EM; Rust, AG; Santos, R; Sapojnikov, V; Schultz, B; Schultz, J; Schwartz, MS; Schwartz, S; Scott, C; Seaman, S; Searle, S; Sharpe, T; Sheridan, A; Shownkeen, R; Sims, S; Singer, JB; Slater, G; Smit, A; Smith, DR; Spencer, B; Stabenau, A; Stange-Thomann, N; Sugnet, C; Suyama, M; Tesler, G; Thompson, J; Torrents, D; Trevaskis, E; Tromp, J; Ucla, C; Ureta-Vidal, A; Vinson, JP; Von Niederhausern, AC; Wade, CM; Wall, M; Weber, RJ; Weiss, RB; Wendl, MC; West, AP; Wetterstrand, K; Wheeler, R; Whelan, S; Wierzbowski, J; Willey, D; Williams, S; Wilson, RK; Winter, E; Worley, KC; Wyman, D; Yang, S; Yang, S-P; Zdobnov, EM; Zody, MC; Lander, ES

Published Date

  • December 2002

Published In

Volume / Issue

  • 420 / 6915

Start / End Page

  • 520 - 562

PubMed ID

  • 12466850

Pubmed Central ID

  • 12466850

Electronic International Standard Serial Number (EISSN)

  • 1476-4687

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/nature01262

Language

  • eng