A randomized controlled trial of epoprostenol therapy for severe congestive heart failure: The Flolan International Randomized Survival Trial (FIRST).

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

This trial evaluated the effects of epoprostenol on patients with severe left ventricular failure. Patients with class IIIB/IV congestive heart failure and decreased left ventricular ejection fraction were eligible for enrollment if angiography documented severely compromised hemodynamics while the patient was receiving a regimen of digoxin, diuretics, and an angiotensin-converting enzyme inhibitor. We randomly assigned 471 patients to epoprostenol infusion or standard care. The primary end point was survival; secondary end points were clinical events, congestive heart failure symptoms, distance walked in 6 minutes, and quality-of-life measures. The median dose of epoprostenol was 4.0 ng/kg/min, resulting in a significant increase in cardiac index (1.81 to 2.61 L/min/m2), a decrease in pulmonary capillary wedge pressure (24.5 to 20.0 mm Hg), and a decrease in systemic vascular resistance (20.76 to 12.33 units). The trial was terminated early because of a strong trend toward decreased survival in the patients treated with epoprostenol. Chronic intravenous epoprostenol therapy is not associated with improvement in distance walked, quality of life, or morbid events and is associated with an increased risk of death.

Full Text

Duke Authors

Cited Authors

  • Califf, RM; Adams, KF; McKenna, WJ; Gheorghiade, M; Uretsky, BF; McNulty, SE; Darius, H; Schulman, K; Zannad, F; Handberg-Thurmond, E; Harrell, FE; Wheeler, W; Soler-Soler, J; Swedberg, K

Published Date

  • July 1997

Published In

Volume / Issue

  • 134 / 1

Start / End Page

  • 44 - 54

PubMed ID

  • 9266782

International Standard Serial Number (ISSN)

  • 0002-8703

Digital Object Identifier (DOI)

  • 10.1016/s0002-8703(97)70105-4


  • eng

Conference Location

  • United States